FMOC-p-羧基-Phe(OtBu)-OH合成路线 （共 6 条）
反应条件
1: 95 percent / Cs2CO3 / methanol; H2O; dimethylformamide 2: 75 percent / 2,6-lutidine / CH2Cl2 / -40 °C 3: 89 percent / AcOK, 1,1'-bis(diphenylphosphino)ferrocene / Pd(OAc)2 / dimethylformamide / 3 h / 60 °C 4: 80 percent / BF3*Et2O / CH2Cl2; cyclohexane / 3 h / Ambient temperature 5: H2 / Pd/C 6: Na2CO3 / H2O; acetone / 2 h / Ambient temperature View Scheme
参考文献
Wang, Wei; Obeyesekere, Nihal U.; McMurray, John S.
Tetrahedron Letters, 1996 , vol. 37, # 37 p. 6661 - 6664
反应条件
1: 75 percent / 2,6-lutidine / CH2Cl2 / -40 °C 2: 89 percent / AcOK, 1,1'-bis(diphenylphosphino)ferrocene / Pd(OAc)2 / dimethylformamide / 3 h / 60 °C 3: 80 percent / BF3*Et2O / CH2Cl2; cyclohexane / 3 h / Ambient temperature 4: H2 / Pd/C 5: Na2CO3 / H2O; acetone / 2 h / Ambient temperature View Scheme
参考文献
Wang, Wei; Obeyesekere, Nihal U.; McMurray, John S.
Tetrahedron Letters, 1996 , vol. 37, # 37 p. 6661 - 6664
反应条件
1: H2 / Pd/C 2: Na2CO3 / H2O; acetone / 2 h / Ambient temperature View Scheme
参考文献
Wang, Wei; Obeyesekere, Nihal U.; McMurray, John S.
Tetrahedron Letters, 1996 , vol. 37, # 37 p. 6661 - 6664
反应条件
1: 80 percent / BF3*Et2O / CH2Cl2; cyclohexane / 3 h / Ambient temperature 2: H2 / Pd/C 3: Na2CO3 / H2O; acetone / 2 h / Ambient temperature View Scheme
参考文献
Wang, Wei; Obeyesekere, Nihal U.; McMurray, John S.
Tetrahedron Letters, 1996 , vol. 37, # 37 p. 6661 - 6664
反应条件
1: 89 percent / AcOK, 1,1'-bis(diphenylphosphino)ferrocene / Pd(OAc)2 / dimethylformamide / 3 h / 60 °C 2: 80 percent / BF3*Et2O / CH2Cl2; cyclohexane / 3 h / Ambient temperature 3: H2 / Pd/C 4: Na2CO3 / H2O; acetone / 2 h / Ambient temperature View Scheme
参考文献
Wang, Wei; Obeyesekere, Nihal U.; McMurray, John S.
Tetrahedron Letters, 1996 , vol. 37, # 37 p. 6661 - 6664
反应条件
sodium carbonate in water; acetone 2 h; Ambient temperature; Yield given;
参考文献
Wang, Wei; Obeyesekere, Nihal U.; McMurray, John S.
Tetrahedron Letters, 1996 , vol. 37, # 37 p. 6661 - 6664
