7β,10β-二甲氧基多西紫杉醇合成路线 （共 27 条）
反应条件
water; Raney nickel in methanol T=23°C;
参考文献
PLUS CHEMICALS SA; TEVA PHARMACEUTICALS USA, INC.; SIMO, Ondrej; VRASPIR, Pavel; HOLAS, Tomas; JEGOROV, Alexandr; GABRIEL, Roman
Patent: WO2012/142117 A1, 2012 ;
Location in patent: Page/Page column 33 ;
反应条件
potassium hydride in tetrahydrofuran T=0 - 20°C;
参考文献
ScinoPharm Taiwan Ltd.; Hsiao, TsungYu; Tseng, HsinChang
Patent: US2013/90484 A1, 2013 ;
Location in patent: Paragraph 0046-0047 ;
反应条件
hydrogen in N,N-dimethyl-formamide T=20°C; P=2584.17 Torr; 15 h; SolventPressureTemperatureTime;
参考文献
Scinopharm Taiwan, LTD.; Hsiao, TsungYu; Henschke, Julian Paul; Tseng, HsinChang
Patent: US2013/116444 A1, 2013 ;
Location in patent: Paragraph 0167 ;
反应条件
1: 10-deacetyl baccatin III With lithium hexamethyldisilazane in tetrahydrofuran T=-72°C; 0.666667 h; Inert atmosphere; 2: methyl trifluoromethanesulfonate in tetrahydrofuran T=-72°C; 4.08333 h; Inert atmosphere;
参考文献
Jing, Yun-Rong; Zhou, Wei; Li, Wan-Liang; Zhao, Lin-Xiang; Wang, Yong-Feng
Bioorganic and Medicinal Chemistry, 2014 , vol. 22, # 1 p. 194 - 203
反应条件
hydrazine hydrate in N,N-dimethyl-formamide T=23°C; 18 h; Inert atmosphere;
参考文献
PLUS CHEMICALS SA; TEVA PHARMACEUTICALS USA, INC.; SIMO, Ondrej; VRASPIR, Pavel; HOLAS, Tomas; JEGOROV, Alexandr; GABRIEL, Roman
Patent: WO2012/142117 A1, 2012 ;
Location in patent: Page/Page column 33 ;
反应条件
tetrabutyl ammonium fluoride in tetrahydrofuran T=0 - 5°C; Inert atmosphere;
参考文献
FRESENIUS KABI ONCOLOGY LIMITED; LAHIRI, Saswata; GUPTA, Nitin; AZIM, Abul; PANDA, Nilendu; MISHRA, Bhuwan Bhaskar; SANGHANI, Sunil
Patent: US2014/58119 A1, 2014 ;
Location in patent: Page/Page column 11 ;
反应条件
hydrogen in N,N-dimethyl-formamide T=50°C; P=8274.59 Torr; 23 h;
参考文献
Scinopharm Taiwan, LTD.; Hsiao, TsungYu; Henschke, Julian Paul; Tseng, HsinChang
Patent: US2013/116444 A1, 2013 ;
Location in patent: Paragraph 0168 ;
反应条件
hydrogen in N,N-dimethyl-formamide T=20°C; P=2584.17 Torr; 15 h;
参考文献
Scinopharm Taiwan, LTD.; Hsiao, TsungYu; Henschke, Julian Paul; Tseng, HsinChang
Patent: US2013/116444 A1, 2013 ;
Location in patent: Paragraph 0181 ;
反应条件
hydrogen in N,N-dimethyl-formamide T=20°C; P=2584.17 Torr; 15 h;
参考文献
Scinopharm Taiwan, LTD.; Hsiao, TsungYu; Henschke, Julian Paul; Tseng, HsinChang
Patent: US2013/116444 A1, 2013 ;
Location in patent: Paragraph 0169 ;
反应条件
potassium hydride in tetrahydrofuran T=-20 - 20°C; 8 h;
参考文献
YUNG SHIN PHARM. IND. CO., LTD.; KUNG, Liang-Rern; HUNG, Yi-Ting; FANG, Tung-Shen; CHANG, Po-Wei; HUANG, Tsang-Miao
Patent: WO2014/22237 A1, 2014 ;
Location in patent: Page/Page column 6 ;
