7β,10β-二甲氧基多西紫杉醇合成路线 （共 27 条）
反应条件
CsBr; sodium hydride in tetrahydrofuran; N,N-dimethyl-formamide T=-20 - 20°C; 2.33333 h; Inert atmosphere;
参考文献
YUNG SHIN PHARM. IND. CO., LTD.; KUNG, Liang-Rern; HUNG, Yi-Ting; FANG, Tung-Shen; CHANG, Po-Wei; HUANG, Tsang-Miao
Patent: WO2014/22237 A1, 2014 ;
Location in patent: Page/Page column 6; 7 ;
反应条件
CsBr; sodium hydride in tetrahydrofuran; N,N-dimethyl-formamide T=-20 - 20°C; 2.33333 h; Inert atmosphere;
参考文献
YUNG SHIN PHARM. IND. CO., LTD.; KUNG, Liang-Rern; HUNG, Yi-Ting; FANG, Tung-Shen; CHANG, Po-Wei; HUANG, Tsang-Miao
Patent: WO2014/22237 A1, 2014 ;
Location in patent: Page/Page column 7 ;
反应条件
CsBr; sodium hydride in tetrahydrofuran; N,N-dimethyl-formamide; mineral oil T=-20 - 20°C; 2 h; Inert atmosphere; Product distribution / selectivity;
参考文献
YUNG SHIN PHARM. IND. CO., LTD.; KUNG, Liang-Rern; HUNG, Yi-Ting; FANG, Tung-Shen; CHANG, Po-Wei; HUANG, Tsang-Miao
Patent: WO2014/22237 A1, 2014 ;
Location in patent: Page/Page column 5; 6 ;
反应条件
1: acetic anhydride; acetic acid / 120 h / 23 °C / Inert atmosphere 2: water / Raney nickel / methanol / 23 °C View Scheme
参考文献
PLUS CHEMICALS SA; TEVA PHARMACEUTICALS USA, INC.; SIMO, Ondrej; VRASPIR, Pavel; HOLAS, Tomas; JEGOROV, Alexandr; GABRIEL, Roman
Patent: WO2012/142117 A1, 2012 ;
反应条件
1: hydrazine hydrate / N,N-dimethyl-formamide / 20 h / 0 °C / Inert atmosphere 2: acetic anhydride; acetic acid / 120 h / 23 °C / Inert atmosphere 3: water / Raney nickel / methanol / 23 °C 4: hydrazine hydrate / N,N-dimethyl-formamide / 18 h / 23 °C / Inert atmosphere View Scheme
参考文献
PLUS CHEMICALS SA; TEVA PHARMACEUTICALS USA, INC.; SIMO, Ondrej; VRASPIR, Pavel; HOLAS, Tomas; JEGOROV, Alexandr; GABRIEL, Roman
Patent: WO2012/142117 A1, 2012 ;
反应条件
1: acetic anhydride; acetic acid / 120 h / 23 °C / Inert atmosphere 2: water / Raney nickel / methanol / 23 °C 3: hydrazine hydrate / N,N-dimethyl-formamide / 18 h / 23 °C / Inert atmosphere View Scheme
参考文献
PLUS CHEMICALS SA; TEVA PHARMACEUTICALS USA, INC.; SIMO, Ondrej; VRASPIR, Pavel; HOLAS, Tomas; JEGOROV, Alexandr; GABRIEL, Roman
Patent: WO2012/142117 A1, 2012 ;
反应条件
1: water / Raney nickel / methanol / 23 °C 2: hydrazine hydrate / N,N-dimethyl-formamide / 18 h / 23 °C / Inert atmosphere View Scheme
参考文献
PLUS CHEMICALS SA; TEVA PHARMACEUTICALS USA, INC.; SIMO, Ondrej; VRASPIR, Pavel; HOLAS, Tomas; JEGOROV, Alexandr; GABRIEL, Roman
Patent: WO2012/142117 A1, 2012 ;
反应条件
1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / -20 - 20 °C 2: tetrabutyl ammonium fluoride / tetrahydrofuran / 20 °C 3: potassium hydride / tetrahydrofuran / 0 - 20 °C View Scheme
参考文献
Scinopharm Taiwan, LTD.; Hsiao, TsungYu; Henschke, Julian Paul; Tseng, HsinChang
Patent: US2013/116444 A1, 2013 ;
反应条件
1: tetrabutyl ammonium fluoride / tetrahydrofuran / 20 °C 2: potassium hydride / tetrahydrofuran / 0 - 20 °C View Scheme
参考文献
Scinopharm Taiwan, LTD.; Hsiao, TsungYu; Henschke, Julian Paul; Tseng, HsinChang
Patent: US2013/116444 A1, 2013 ;
反应条件
1: sodium hydride / tetrahydrofuran / -5 - 0 °C 2: tetrabutyl ammonium fluoride / tetrahydrofuran / 0 - 5 °C / |Inert atmosphere 3: sodium hydride / tetrahydrofuran / -5 - 0 °C 4: tetrabutyl ammonium fluoride / tetrahydrofuran / 0 - 5 °C / |Inert atmosphere View Scheme
参考文献
FRESENIUS KABI ONCOLOGY LIMITED; LAHIRI, Saswata; GUPTA, Nitin; AZIM, Abul; PANDA, Nilendu; MISHRA, Bhuwan Bhaskar; SANGHANI, Sunil
Patent: US2014/58119 A1, 2014 ;
