7β,10β-二甲氧基多西紫杉醇合成路线 （共 27 条）
反应条件
1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0 - 5 °C / |Inert atmosphere 2: sodium hydride / tetrahydrofuran / -5 - 0 °C 3: tetrabutyl ammonium fluoride / tetrahydrofuran / 0 - 5 °C / |Inert atmosphere View Scheme
参考文献
FRESENIUS KABI ONCOLOGY LIMITED; LAHIRI, Saswata; GUPTA, Nitin; AZIM, Abul; PANDA, Nilendu; MISHRA, Bhuwan Bhaskar; SANGHANI, Sunil
Patent: US2014/58119 A1, 2014 ;
反应条件
1: methanol; sodium tetrahydroborate / tetrahydrofuran / 3 h / 20 °C 2: hydrogen / N,N-dimethyl-formamide / 23 h / 50 °C / 8274.59 Torr View Scheme
参考文献
Scinopharm Taiwan, LTD.; Hsiao, TsungYu; Henschke, Julian Paul; Tseng, HsinChang
Patent: US2013/116444 A1, 2013 ;
反应条件
1: pyridine / dichloromethane / 20 °C 2: hydrogen / N,N-dimethyl-formamide / 15 h / 20 °C / 2584.17 Torr View Scheme
参考文献
Scinopharm Taiwan, LTD.; Hsiao, TsungYu; Henschke, Julian Paul; Tseng, HsinChang
Patent: US2013/116444 A1, 2013 ;
反应条件
1: 4-(N,N-dimethlyamino)pyridine; dicyclohexyl-carbodiimide / tetrahydrofuran 2: water; hydrogenchloride / methanol / 20 °C View Scheme
参考文献
Scinopharm Taiwan, LTD.; Hsiao, TsungYu; Henschke, Julian Paul; Tseng, HsinChang
Patent: US2013/116444 A1, 2013 ;
反应条件
1: lithium hexamethyldisilazane / N,N-dimethyl-formamide; tetrahydrofuran / 1.58 h / 20 °C / Inert atmosphere 2: toluene-4-sulfonic acid / tetrahydrofuran; methanol / 1 h / 0 - 5 °C View Scheme
参考文献
PLUS CHEMICALS SA; TEVA PHARMACEUTICALS USA, INC.; SIMO, Ondrej; VRASPIR, Pavel; HOLAS, Tomas; JEGOROV, Alexandr; GABRIEL, Roman
Patent: WO2012/142117 A1, 2012 ;
反应条件
1: lithium hexamethyldisilazane / N,N-dimethyl-formamide; tetrahydrofuran / 1.08 h / 20 °C / Inert atmosphere 2: toluene-4-sulfonic acid / butan-1-ol / 1 h / 50 °C View Scheme
参考文献
FRESENIUS KABI ONCOLOGY LIMITED; LAHIRI, Saswata; GUPTA, Nitin; AZIM, Abul; PANDA, Nilendu; MISHRA, Bhuwan Bhaskar; SANGHANI, Sunil
Patent: US2014/58119 A1, 2014 ;
反应条件
1: dicyclohexyl-carbodiimide; 4-(N,N-dimethlyamino)pyridine; toluene-4-sulfonic acid / dichloromethane / 20 °C / |Inert atmosphere 2: acetyl chloride / tetrahydrofuran; methanol / 2 h / 0 °C / |Inert atmosphere View Scheme
参考文献
Jing, Yun-Rong; Zhou, Wei; Li, Wan-Liang; Zhao, Lin-Xiang; Wang, Yong-Feng
Bioorganic and Medicinal Chemistry, 2014 , vol. 22, # 1 p. 194 - 203
