1: With n-butyllithium in tetrahydrofuran T=-78°C; Metallation; 0.25 h; 2: With boric acid trimethyl ester in tetrahydrofuran T=-78 - 20°C; Substitution; 3: With hydrogenchloride; water T=0°C; Hydrolysis; Further stages.;

n-butyllithium in tetrahydrofuran dissolved aromatic bromide in THF, added n-BuLi dropwise, mixt. stirredat -78°C for 15 min; added freshly distd. ((CH3)2CHO)3B, stirredat -78°C for 30 min, warmed to room temp., stirred for further 20 min; cooled to 0°C, acidified, extracted with CH2Cl2, dried, evapd. under vac.;

n-butyllithium in tetrahydrofuran dissolved aromatic bromide in THF, added n-BuLi dropwise, mixt. stirredat -78°C for 15 min; added freshly distd. (CH3O)3B, stirred at -78°C for 30 min, warmed to room temp., stirred for further 20 min; cooled to 0°C, acidified, extracted with CH2Cl2, dried, evapd. under vac.;

1: With sodium carbonate; tetrakis(triphenylphosphine) palladium(0) in ethylene glycol dimethyl ether 6 h; Reflux; 2: With sodium hydroxide in ethanol T=20°C; 0.5 h; 3: With hydrogenchloride in ethanol; water pH=1;