4-(1-羟基乙基)哌啶-1-羧酸叔丁酯合成路线 （共 6 条）
反应条件
sodium tetrahydroborate in ethanol T=20°C; 1 h;
参考文献
BOEHRINGER INGELHEIM INTERNATIONAL GMBH; GINN, John David; SORCEK, Ronald John; TURNER, Michael Robert; WU, Di; WU, Frank
Patent: WO2011/84985 A1, 2011 ;
Location in patent: Page/Page column 85 ;
反应条件
triethylamine in 1,2-dichloro-ethane T=20°C; Reflux;
参考文献
SMITH KLINE BEECHAM CORPORATION a corporation
Patent: US2010/29650 A1, 2010 ;
Location in patent: Page/Page column 77 ;
反应条件
1: in tetrahydrofuran; diethyl ether T=-78 - -50°C; 5 h; 2: With water in tetrahydrofuran; diethyl ether T=-50 - 20°C; 16 h;
参考文献
ELI LILLY AND COMPANY
Patent: US2011/15199 A1, 2011 ;
Location in patent: Page/Page column 6 ;
反应条件
sodium hydroxide; LiAlH4 in tetrahydrofuran; water
参考文献
Chee, Jennifer; Johanson, Jill N.; Kayser, Frank; Parsons, William H.; Rupprecht, Kathleen M.
Patent: US2002/13348 A1, 2002 ;
反应条件
lithium borohydride in methanol; diethyl ether; water
参考文献
Takeda Chemical Industries, Ltd.
Patent: US5753664 A1, 1998 ;
反应条件
1: With hydrogenchloride; methanol in diethyl ether T=20°C; 2: With sodium hydroxide in diethyl ether
参考文献
WO2011/84985 A1, ;
Page/Page column 85 ;
