(R)-3-氨基-2-苄基丙酸合成路线 （共 27 条）
反应条件
1: LHMDS / tetrahydrofuran / 0.5 h / -78 °C
2: HCOONH4 / 10percent Pd/C / methanol / 60 °C
View Scheme
参考文献
Lee, Hee-Seung; Park, Jin-Seong; Kim, Byeong Moon; Gellman, Samuel H.
Journal of Organic Chemistry, 2003 , vol. 68, # 4 p. 1575 - 1578
反应条件
1: NaOH, H2O, EDCI / tetrahydrofuran / Ambient temperature
2: DEAD, Ph3P / tetrahydrofuran / Ambient temperature
3: 100 percent / LiOH, H2O / tetrahydrofuran; methanol / 0 °C
4: H2 / 10percent Pd/C / methanol
View Scheme
参考文献
Jin, Yonghao; Kim, Dong H.
Synlett, 1998 , # 11 p. 1189 - 1190
反应条件
1: 100 percent / LiOH, H2O / tetrahydrofuran; methanol / 0 °C
2: H2 / 10percent Pd/C / methanol
View Scheme
参考文献
Jin, Yonghao; Kim, Dong H.
Synlett, 1998 , # 11 p. 1189 - 1190
反应条件
1: DEAD, Ph3P / tetrahydrofuran / Ambient temperature
2: 100 percent / LiOH, H2O / tetrahydrofuran; methanol / 0 °C
3: H2 / 10percent Pd/C / methanol
View Scheme
参考文献
Jin, Yonghao; Kim, Dong H.
Synlett, 1998 , # 11 p. 1189 - 1190
反应条件
hydrogenchloride in water
24 h; Heating;
参考文献
Huang, Hanmin; Liu, Xiongcai; Deng, Jun; Qiu, Min; Zheng, Zhuo
Organic Letters, 2006 , vol. 8, # 15 p. 3359 - 3362
反应条件
1: 69 percent / LiHMDS / tetrahydrofuran / 1.) -72 deg C, 30 min, 2.) -72 to -20 deg C, 2 h
2: 79 percent / TFA / Ambient temperature
3: 60 percent / Et3N, diphenylphosphoryl azide / toluene
4: 67 percent / aq. LiOH, H2O2 / tetrahydrofuran / 0 °C
5: 81 percent / H2, glacial acetic acid / 10percent Pd/C
View Scheme
参考文献
Arvanitis, Elena; Ernst, Holger; Ludwig, Alice A.; Robinson, Andrew J.; Wyatt, Peter B.
Journal of the Chemical Society - Perkin Transactions 1, 1998 , # 3 p. 521 - 528
反应条件
1: 49 percent / Rhodococcus erythropolis AJ270; potassium phosphate buffer / H2O / 3.5 h / pH 7.0
2: 93 percent / hydrogen / Pd/C / methanol / 3 h
View Scheme
参考文献
Ma, Da-You; Wang, De-Xian; Zheng, Qi-Yu; Wang, Mei-Xiang
Tetrahedron Asymmetry, 2006 , vol. 17, # 16 p. 2366 - 2376
反应条件
1: 47 percent / triphenylphosphine; diisopropyl azodicarboxylate; hydrazoic acid / tetrahydrofuran; toluene / 0.02 h / cooling
2: 49 percent / Rhodococcus erythropolis AJ270; potassium phosphate buffer / H2O / 3.5 h / pH 7.0
3: 93 percent / hydrogen / Pd/C / methanol / 3 h
View Scheme
参考文献
Ma, Da-You; Wang, De-Xian; Zheng, Qi-Yu; Wang, Mei-Xiang
Tetrahedron Asymmetry, 2006 , vol. 17, # 16 p. 2366 - 2376
反应条件
1: 98 percent / NaBH4 / propan-2-ol / 20 °C
2: 47 percent / triphenylphosphine; diisopropyl azodicarboxylate; hydrazoic acid / tetrahydrofuran; toluene / 0.02 h / cooling
3: 49 percent / Rhodococcus erythropolis AJ270; potassium phosphate buffer / H2O / 3.5 h / pH 7.0
4: 93 percent / hydrogen / Pd/C / methanol / 3 h
View Scheme
参考文献
Ma, Da-You; Wang, De-Xian; Zheng, Qi-Yu; Wang, Mei-Xiang
Tetrahedron Asymmetry, 2006 , vol. 17, # 16 p. 2366 - 2376
反应条件
1: 60 percent / Et3N, diphenylphosphoryl azide / toluene
2: 67 percent / aq. LiOH, H2O2 / tetrahydrofuran / 0 °C
3: 81 percent / H2, glacial acetic acid / 10percent Pd/C
View Scheme
参考文献
Arvanitis, Elena; Ernst, Holger; Ludwig, Alice A.; Robinson, Andrew J.; Wyatt, Peter B.
Journal of the Chemical Society - Perkin Transactions 1, 1998 , # 3 p. 521 - 528
