3,3,5-三溴-1H-吡咯[2,3-b]吡啶-2-酮合成路线 （共 9 条）
反应条件
bromine in water; tert-butyl alcohol T=0 - 20°C;
参考文献
WO2003/82869 A1, ;
Page/Page column 23 ;
WO 03/082869 A1
反应条件
bromine in water; tert-butyl alcohol 19 h; Ambient temperature;
参考文献
Heterocycles, , vol. 50, # 2 p. 1065 - 1080
反应条件
pyridinium tribromide; acetic acid in ethanol; tert-butyl alcohol 2 h;
参考文献
WO2005/5378 A2, ;
Page/Page column 43 ;
WO 2005/005378 A2
反应条件
1.1: 95 percent / zinc; acetic acid / 5 h / 20 °C 2.1: BH3*THF / tetrahydrofuran / 0.83 h / 20 °C 2.2: 50 percent / Mn(OAc)3*2H2O; acetic acid / 0.83 h / 75 °C 3.1: 85 percent / CuBr / methanol; dimethylformamide / 3 h / Heating 4.1: 60 percent / POCl3 / 3.5 h / 0 - 80 °C View Scheme
参考文献
Mazeas, Daniel; Guillaumet, Gerald; Viaud, Marie-Claude
Heterocycles, 1999 , vol. 50, # 2 p. 1065 - 1080
反应条件
1.1: 94 percent / zinc; acetic acid / 20 °C 2.1: borane*tetrahydrofurane / tetrahydrofuran / 0.58 h / 0 - 20 °C 2.2: 50 percent / manganese triacetate / acetic acid / 0.75 h / 75 °C 3.1: sodium hydride in oil / dimethylformamide / 0.5 h / 0 °C 3.2: 63 percent / dimethylformamide / 12 h / 0 - 20 °C View Scheme
参考文献
Guillard, Jerome; Larraya, Carlos; Viaud-Massuard, Marie-Claude
Heterocycles, 2003 , vol. 60, # 4 p. 865 - 877
反应条件
1.1: 95 percent / zinc; acetic acid / 5 h / 20 °C 2.1: BH3*THF / tetrahydrofuran / 0.83 h / 20 °C 2.2: 50 percent / Mn(OAc)3*2H2O; acetic acid / 0.83 h / 75 °C View Scheme
参考文献
Mazeas, Daniel; Guillaumet, Gerald; Viaud, Marie-Claude
Heterocycles, 1999 , vol. 50, # 2 p. 1065 - 1080
反应条件
acetic acid; zinc T=20°C; 5 h;
参考文献
Journal of the American Chemical Society, , vol. 128, # 45 p. 14426 - 14427
反应条件
1.1: 95 percent / zinc; acetic acid / 5 h / 20 °C 2.1: BH3*THF / tetrahydrofuran / 0.83 h / 20 °C 2.2: 50 percent / Mn(OAc)3*2H2O; acetic acid / 0.83 h / 75 °C 3.1: 85 percent / CuBr / methanol; dimethylformamide / 3 h / Heating View Scheme
参考文献
Mazeas, Daniel; Guillaumet, Gerald; Viaud, Marie-Claude
Heterocycles, 1999 , vol. 50, # 2 p. 1065 - 1080
反应条件
1.1: 94 percent / zinc; acetic acid / 20 °C
2.1: borane*tetrahydrofurane / tetrahydrofuran / 0.58 h / 0 - 20 °C
2.2: 50 percent / manganese triacetate / acetic acid / 0.75 h / 75 °C
3.1: 54 percent / sodium hydride in oil / dimethylformamide / 12 h / 0 - 20 °C
View Scheme
参考文献
Guillard, Jerome; Larraya, Carlos; Viaud-Massuard, Marie-Claude
Heterocycles, 2003 , vol. 60, # 4 p. 865 - 877
