反应条件
1.1: copper(I) bromide / N,N-dimethyl-formamide; methanol / 2.5 h / 140 °C
2.1: sodium hydroxide; benzyl-tri-(n-butyl)-ammonium bromide / dichloromethane / 2.25 h / 0 - 20 °C
3.1: lithium diisopropyl amide / toluene; tetrahydrofuran; ethylbenzene / 0.5 h / -60 °C
3.2: -60 - 20 °C
4.1: sodium hydroxide; water / methanol / 0.5 h / 80 °C
View Scheme
参考文献
IRONWOOD PHARMACEUTICALS, INC.; HUDSON, Colleen; BARDEN, Timothy, C.; JIA, James; MERMERIAN, Ara; PENG, Bo; YANG, Jane; YU, Xiang, Y.; SPROTT, Kevin
Patent: WO2012/88469 A1, 2012 ;
WO 2012/088469 A1