5-甲氧基-7-氮杂吲哚合成路线 （共 15 条）
反应条件
copper(I) bromide in methanol; N,N-dimethyl-formamide 3 h; Heating;
参考文献
Wu, Pei-Wen; Hsieh, Wan-Ting; Cheng, Yi-Ming; Wei, Ching-Yen; Chou, Pi-Tai
Journal of the American Chemical Society, 2006 , vol. 128, # 45 p. 14426 - 14427
反应条件
sodium; copper(I) bromide in N,N-dimethyl-formamide 5 h; Inert atmosphereReflux;
参考文献
Berthel, Steven Joseph; Chen, Li; Corbett, Wendy Lea; Feng, LiChun; Haynes, Nancy-Ellen; Kester, Robert Francis; So, Sung-Sau; Tilley, Jefferson Wright
Patent: US2011/144105 A1, 2011 ;
Location in patent: Page/Page column 20 ;
反应条件
copper(l) iodide in N,N-dimethyl-formamide T=120°C; Product distribution / selectivity;
参考文献
PLEXXIKON, INC.
Patent: WO2008/79909 A1, 2008 ;
Location in patent: Page/Page column 64-65 ;
反应条件
1.1: BH3*THF / tetrahydrofuran / 0.83 h / 20 °C 1.2: 50 percent / Mn(OAc)3*2H2O; acetic acid / 0.83 h / 75 °C 2.1: 85 percent / CuBr / methanol; dimethylformamide / 3 h / Heating View Scheme
参考文献
Journal of the American Chemical Society, , vol. 128, # 45 p. 14426 - 14427
反应条件
1.1: 95 percent / zinc; acetic acid / 5 h / 20 °C 2.1: BH3*THF / tetrahydrofuran / 0.83 h / 20 °C 2.2: 50 percent / Mn(OAc)3*2H2O; acetic acid / 0.83 h / 75 °C 3.1: 85 percent / CuBr / methanol; dimethylformamide / 3 h / Heating View Scheme
参考文献
Journal of the American Chemical Society, , vol. 128, # 45 p. 14426 - 14427
反应条件
1.1: 85 percent / bromine / 2-methyl-propan-2-ol; H2O / 24 h / 24.84 °C 2.1: 95 percent / zinc; acetic acid / 5 h / 20 °C 3.1: BH3*THF / tetrahydrofuran / 0.83 h / 20 °C 3.2: 50 percent / Mn(OAc)3*2H2O; acetic acid / 0.83 h / 75 °C 4.1: 85 percent / CuBr / methanol; dimethylformamide / 3 h / Heating View Scheme
参考文献
Journal of the American Chemical Society, , vol. 128, # 45 p. 14426 - 14427
反应条件
1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.5 h / 25 °C 2: copper(I) bromide; sodium / N,N-dimethyl-formamide / 5 h / Inert atmosphere; Reflux View Scheme
反应条件
1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C 1.2: 3 h / 0 °C 2.1: bromine; pyridine / dichloromethane / 2 h / 0 °C 3.1: 2,3-dicyano-5,6-dichloro-p-benzoquinone / dichloromethane / 1 h 4.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.5 h / 25 °C 5.1: copper(I) bromide; sodium / N,N-dimethyl-formamide / 5 h / Inert atmosphere; Reflux View Scheme
反应条件
trichlorophosphate T=0 - 80°C; Vilsmeier reaction; 3.5 h;
参考文献
Wu, Pei-Wen; Hsieh, Wan-Ting; Cheng, Yi-Ming; Wei, Ching-Yen; Chou, Pi-Tai
Journal of the American Chemical Society, 2006 , vol. 128, # 45 p. 14426 - 14427
反应条件
Vilsmeier-Haack Reaction;
参考文献
PLEXXIKON, INC.
Patent: WO2005/9958 A1, 2005 ;
Location in patent: Page 158-159 ;
WO 2005/009958 A1
