5-甲氧基-7-氮杂吲哚合成路线 （共 15 条）
反应条件
sodium hydroxide; boron tribromide in dichloromethane
参考文献
AstraZeneca AB
Patent: EP1154774 B1, 2005 ;
Location in patent: Page/Page column 113 ;
反应条件
1: 0.51 g / sodium hydride / dimethylformamide / 13 h / 0 - 20 °C
2: 85 percent / boron tribromide / CH2Cl2 / 0 - 20 °C
View Scheme
参考文献
Larraya, Carlos; Guillard, Jerome; Renard, Pierre; Audinot, Valerie; Boutin, Jean A.; Delagrange, Philippe; Bennejean, Caroline; Viaud-Massuard, Marie-Claude
European Journal of Medicinal Chemistry, 2004 , vol. 39, # 6 p. 515 - 526
反应条件
1.1: sodium hydroxide; benzyl-tri-(n-butyl)-ammonium bromide / dichloromethane / 2.25 h / 0 - 20 °C
2.1: lithium diisopropyl amide / toluene; tetrahydrofuran; ethylbenzene / 0.5 h / -60 °C
2.2: -60 - 20 °C
3.1: sodium hydroxide; water / methanol / 0.5 h / 80 °C
View Scheme
参考文献
IRONWOOD PHARMACEUTICALS, INC.; HUDSON, Colleen; BARDEN, Timothy, C.; JIA, James; MERMERIAN, Ara; PENG, Bo; YANG, Jane; YU, Xiang, Y.; SPROTT, Kevin
Patent: WO2012/88469 A1, 2012 ;
WO 2012/088469 A1
反应条件
1: 5-methoxy-1H-pyrrololt;2,3-bgt;pyridine With tetrabutylammomium bromide; sodium hydroxide in dichloromethane
T=0°C; 0.0833333 h;
2: benzenesulfonyl chloride in dichloromethane
T=0 - 25°C; 12.25 h;
参考文献
Berthel, Steven Joseph; Chen, Li; Corbett, Wendy Lea; Feng, LiChun; Haynes, Nancy-Ellen; Kester, Robert Francis; So, Sung-Sau; Tilley, Jefferson Wright
Patent: US2011/144105 A1, 2011 ;
Location in patent: Page/Page column 20 ;
反应条件
N-benzyl-N,N,N-triethylammonium chloride in dichloromethane
参考文献
Hennequin, Lawrent Francois Andre
Patent: US2003/207878 A1, 2003 ;
US 20030207878 A1
