5-甲氧基-1H-吡咯并[2,3-b]吡啶-3-甲醛合成路线 （共 6 条）
反应条件
trichlorophosphate T=0 - 80°C; Vilsmeier reaction; 3.5 h;
参考文献
Wu, Pei-Wen; Hsieh, Wan-Ting; Cheng, Yi-Ming; Wei, Ching-Yen; Chou, Pi-Tai
Journal of the American Chemical Society, 2006 , vol. 128, # 45 p. 14426 - 14427
反应条件
1.1: BH3*THF / tetrahydrofuran / 0.83 h / 20 °C 1.2: 50 percent / Mn(OAc)3*2H2O; acetic acid / 0.83 h / 75 °C 2.1: 85 percent / CuBr / methanol; dimethylformamide / 3 h / Heating 3.1: 60 percent / POCl3 / 3.5 h / 0 - 80 °C View Scheme
参考文献
Mazeas, Daniel; Guillaumet, Gerald; Viaud, Marie-Claude
Heterocycles, 1999 , vol. 50, # 2 p. 1065 - 1080
反应条件
1: 85 percent / CuBr / methanol; dimethylformamide / 3 h / Heating 2: 60 percent / POCl3 / 3.5 h / 0 - 80 °C View Scheme
参考文献
Mazeas, Daniel; Guillaumet, Gerald; Viaud, Marie-Claude
Heterocycles, 1999 , vol. 50, # 2 p. 1065 - 1080
反应条件
1.1: 95 percent / zinc; acetic acid / 5 h / 20 °C 2.1: BH3*THF / tetrahydrofuran / 0.83 h / 20 °C 2.2: 50 percent / Mn(OAc)3*2H2O; acetic acid / 0.83 h / 75 °C 3.1: 85 percent / CuBr / methanol; dimethylformamide / 3 h / Heating 4.1: 60 percent / POCl3 / 3.5 h / 0 - 80 °C View Scheme
参考文献
Mazeas, Daniel; Guillaumet, Gerald; Viaud, Marie-Claude
Heterocycles, 1999 , vol. 50, # 2 p. 1065 - 1080
反应条件
1.1: 85 percent / bromine / 2-methyl-propan-2-ol; H2O / 24 h / 24.84 °C 2.1: 95 percent / zinc; acetic acid / 5 h / 20 °C 3.1: BH3*THF / tetrahydrofuran / 0.83 h / 20 °C 3.2: 50 percent / Mn(OAc)3*2H2O; acetic acid / 0.83 h / 75 °C 4.1: 85 percent / CuBr / methanol; dimethylformamide / 3 h / Heating 5.1: 60 percent / POCl3 / 3.5 h / 0 - 80 °C View Scheme
参考文献
Mazeas, Daniel; Guillaumet, Gerald; Viaud, Marie-Claude
Heterocycles, 1999 , vol. 50, # 2 p. 1065 - 1080
反应条件
Vilsmeier-Haack Reaction;
参考文献
PLEXXIKON, INC.
Patent: WO2005/9958 A1, 2005 ;
Location in patent: Page 158-159 ;
WO 2005/009958 A1
