4-(2-氨基甲酰苯并呋喃-5-基)哌嗪-1-羧酸叔丁酯合成路线 （共 4 条）
反应条件
in methanol hydrochloric acid
参考文献
US5723614 A1, ;
US 5723614 A
反应条件
1: tert-butyl 4-(3-formyl-4-hydroxyphenyl)piperazine-1-carboxylate With potassium carbonate in N,N-dimethyl-formamide
T=20°C; 0.25 h;
2: bromo-malonic acid ethyl ester-amide in N,N-dimethyl-formamide
T=20 - 120°C; 7 h;
参考文献
MERCK PATENT GMBH
Patent: US2010/36139 A1, 2010 ;
Location in patent: Page/Page column 4 ;
反应条件
hydrogenchloride; Pd(dba)2 in diethylene glycol dimethyl ether; water
参考文献
Bathe, Andreas; Emmert, Steffen; Helfert, Bernd; Boettcher, Henning
Patent: US2003/125558 A1, 2003 ;
参考文献
Bathe, Andreas; Emmert, Steffen; Helfert, Bernd; Boettcher, Henning
Patent: US2003/125558 A1, 2003 ;
