5-(哌嗪-1-基)苯并呋喃-2-甲酰胺合成路线 (共 12 条)
反应条件
1: 1-(2-aminocarbonylbenzofuran-5-yl)piperazine With sodium cyanoborohydride in methanol T=20°C; 2: 3-(4-oxobutyl)-1H-indole-5-carbonitrile in methanol T=20°C; 18 h;
参考文献
DR.REDDYS LABORATORIES LIMITED; IQBAL, Javed; ORUGANTI, Srinivas; RAPOLU, Rajesh Kumar; PEDDY, Vishweshwar; BOGE, Rajesham; PATHIVADA, Deepika; VELAGA, Dharma Jagannadha Rao; YARRAGUNTLA, Sesha Reddy; BADDAM, Sudhakar Reddy; NAREDLA, Anitha; DONIPARTHI, Kiran Kumar; NADGOUD, Ramesh Kumar; PAGADALA, Narasimha Rao; UNNIARAN, Syam Kumar; RAMAKRISHNAN, Srividya
Patent: WO2013/168126 A1, 2013 ;
Location in patent: Page/Page column 81 ;
反应条件
1.1: tributyl-amine / 1-methyl-pyrrolidin-2-one / 8 h / 115 - 120 °C 1.2: 6 h / 25 - 30 °C 2.1: sodium hydrogencarbonate / water; isopropyl alcohol / 65 - 70 °C / pH 7 View Scheme
参考文献
RANBAXY LABORATORIES LIMITED; DAS, Prasenjit; SRIVASTAVA, Bindu; MAHESHWARI, Nitin; MEERAN, Hashim, Nizar, Poovanathil, Nagoor; PRASAD, Mohan; ARORA, Sudershan, Kumar
Patent: WO2014/61004 A2, 2014 ;