4-氯-6,7-二(2-甲氧基乙氧基)喹唑啉合成路线 （共 24 条）
反应条件
1: 90 percent / 160 °C 2: 100 percent / POCl3; diisopropylethylamine / toluene / Heating View Scheme
参考文献
Tetrahedron Letters, , vol. 47, # 15 p. 2539 - 2542
反应条件
1.1: acetic anhydride / 110 °C 2.1: 85 percent / aq. nitric acid / acetic acid / 8 h / 45 - 50 °C 3.1: FeCl3; hydrazine hydrate / H2O; methanol / 3 h / Heating 3.2: 81 percent / HCl / H2O / 90 - 130 °C 4.1: 94 percent / thionyl chloride / dimethylformamide / 2 h / Heating View Scheme
参考文献
Heterocycles, , vol. 71, # 1 p. 39 - 48
反应条件
1.1: 85 percent / aq. nitric acid / acetic acid / 8 h / 45 - 50 °C 2.1: FeCl3; hydrazine hydrate / H2O; methanol / 3 h / Heating 2.2: 81 percent / HCl / H2O / 90 - 130 °C 3.1: 94 percent / thionyl chloride / dimethylformamide / 2 h / Heating View Scheme
参考文献
Heterocycles, , vol. 71, # 1 p. 39 - 48
反应条件
1.1: FeCl3; hydrazine hydrate / H2O; methanol / 3 h / Heating 1.2: 81 percent / HCl / H2O / 90 - 130 °C 2.1: 94 percent / thionyl chloride / dimethylformamide / 2 h / Heating View Scheme
参考文献
Heterocycles, , vol. 71, # 1 p. 39 - 48
反应条件
1.1: hydroxylamine hydrochloride; pyridine / methanol / Heating 2.1: acetic anhydride / 110 °C 3.1: 85 percent / aq. nitric acid / acetic acid / 8 h / 45 - 50 °C 4.1: FeCl3; hydrazine hydrate / H2O; methanol / 3 h / Heating 4.2: 81 percent / HCl / H2O / 90 - 130 °C 5.1: 94 percent / thionyl chloride / dimethylformamide / 2 h / Heating View Scheme
参考文献
Heterocycles, , vol. 71, # 1 p. 39 - 48
反应条件
1.1: 98 percent / potassium carbonate / dimethylformamide / 100 °C 2.1: hydroxylamine hydrochloride; pyridine / methanol / Heating 3.1: acetic anhydride / 110 °C 4.1: 85 percent / aq. nitric acid / acetic acid / 8 h / 45 - 50 °C 5.1: FeCl3; hydrazine hydrate / H2O; methanol / 3 h / Heating 5.2: 81 percent / HCl / H2O / 90 - 130 °C 6.1: 94 percent / thionyl chloride / dimethylformamide / 2 h / Heating View Scheme
参考文献
Heterocycles, , vol. 71, # 1 p. 39 - 48
反应条件
1: With pyridine in isopropyl alcohol T=80°C; 1 h; 2: With hydrogenchloride in 1,4-dioxane; diethyl ether; chloroform T=20°C; 1 h; Product distribution / selectivity;
参考文献
Esteve Química, S.A.
Patent: EP2348020 A1, 2011 ;
Location in patent: Page/Page column 11 ;
反应条件
in isopropyl alcohol T=80°C; 0.533333 h; Microwave irradiation;
参考文献
Tetrahedron, , vol. 66, # 4 p. 962 - 968
反应条件
1.1: pyridine / isopropyl alcohol / 1 h / 80 °C 1.2: 1 h / 20 °C 2.1: trichlorophosphate / N,N-dimethyl-formamide / 0.5 h / 80 °C 2.2: 0.5 h / 0 - 40 °C 3.1: toluene; tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere 3.2: 4 h / 20 °C View Scheme
反应条件
in isopropyl alcohol 18 h; Heating;
参考文献
Norris, Timothy; Santafianos, Dinos
Journal of the Chemical Society. Perkin Transactions 2, 2000 , # 12 p. 2498 - 2502
