4-氯-6,7-二(2-甲氧基乙氧基)喹唑啉合成路线 （共 24 条）
反应条件
in isopropyl alcohol T=25 - 45°C; 4 h; Inert atmosphere;
参考文献
LAURUS LABS PRIVATE LIMITED; SIMHADRI, Srinivas; BIRADAR, Arun, Gunwanthrao; INDUKURI, Venkata, Sunil, Kumar; GORANTLA, Seeta, Ramanjaneyulu; CHAVA, Satyanarayana
Patent: WO2013/156835 A1, 2013 ;
Location in patent: Page/Page column 13; 14 ;
反应条件
1: With pyridine in isopropyl alcohol T=80°C; 1 h; 2: With hydrogenchloride in 1,4-dioxane; diethyl ether; chloroform T=20°C; 1 h; Product distribution / selectivity;
参考文献
Esteve Química, S.A.
Patent: EP2348020 A1, 2011 ;
Location in patent: Page/Page column 11 ;
反应条件
1.1: pyridine / isopropyl alcohol / 1 h / 80 °C 1.2: 1 h / 20 °C 2.1: trichlorophosphate / N,N-dimethyl-formamide / 0.5 h / 80 °C 2.2: 0.5 h / 0 - 40 °C 3.1: lithium diisopropyl amide / n-heptane; tetrahydrofuran; ethylbenzene / 0.5 h / 0 °C / Inert atmosphere 3.2: 15 h / 20 °C 3.3: 3 h / 20 °C View Scheme
参考文献
Esteve Química, S.A.
Patent: EP2348020 A1, 2011 ;
反应条件
in isopropyl alcohol 1.5 - 2 h; Heating / reflux; Product distribution / selectivity;
参考文献
HETERO DRUGS LIMITED
Patent: WO2009/7984 A2, 2009 ;
Location in patent: Page/Page column 9-10 ;
