2-氨基-3-甲基-5-硝基吡啶合成路线 （共 14 条）
反应条件
1: With sulfuric acid; nitric acid T=0 - 50°C; 2: With ammonia in water T=20°C;
参考文献
Phenex Pharmaceuticals AG
Patent: EP1894924 A1, 2008 ;
Location in patent: Page/Page column 36 ;
反应条件
4-amino-1,2,4-(4H)triazole; potassium tert-butylate in dimethyl sulfoxide T=20°C; 5 h;
参考文献
Bakke, Jan M.; Svensen, Harald; Trevisan, Raffaela
Journal of the Chemical Society. Perkin Transactions 1, 2001 , # 4 p. 376 - 378
反应条件
triethylamine in ethanol 3 h; Heatingvar. amidines, time, solv. and temp.; Product distribution;
参考文献
Journal of Organic Chemistry, , vol. 47, # 6 p. 1077 - 1080
反应条件
in methanol 0.5 h; Irradiation;
参考文献
Sepiol, Jadwiga; Tomasik, Piotr
Acta Chimica Hungarica, 1986 , vol. 121, # 4 p. 333 - 338
参考文献
Chemische Berichte, , vol. 57, p. 1804
Chemische Berichte, , vol. 58, p. 1733
反应条件
iron; ammonium chloride in ethanol; water T=80°C; 3 h;
参考文献
ARRAY BIOPHARMA INC.; GENENTECH, INC.; AHRENDT, Kateri A.; BUCKMELTER, Alexandre J.; GRINA, Jonas; HANSEN, Joshua D.; LAIRD, Ellen R.; NEWHOUSE, Brad; REN, Li; WENGLOWSKY, Steven Mark; FENG, Bainian; MALESKY, Kim; MATHIEU, Simon; RUDOLPH, Joachim; WEN, Zhaoyang; YOUNG, Wendy B.
Patent: WO2009/111280 A1, 2009 ;
Location in patent: Page/Page column 55 ;
WO 2009/111280 A1
反应条件
1: calcium chloride; aqueous sodium nitrite solution; aqueous hydrochloric acid / Erhitzen des Reaktionsprodukts mit Wasser 2: phosphoryl chloride 3: palladium/charcoal; sodium acetate; acetic acid / Hydrogenation 4: ethyl nitrite / Erwaermen des erhaltenen Diazoniumsalzes mit Petrolaether View Scheme
参考文献
Hawkins; Roe
Journal of Organic Chemistry, 1949 , vol. 14, p. 328,331
反应条件
hydrazine in water T=110 - 120°C; 5 h;
参考文献
Russian Journal of Organic Chemistry, , vol. 45, # 1 p. 115 - 118
反应条件
1: calcium chloride; aqueous sodium nitrite solution; aqueous hydrochloric acid / Erhitzen des Reaktionsprodukts mit Wasser 2: phosphoryl chloride 3: palladium/charcoal; sodium acetate; acetic acid / Hydrogenation 4: ethyl nitrite / Erwaermen des erhaltenen Diazoniumsalzes mit Petrolaether 5: KMnO4; H2O View Scheme
参考文献
Hawkins; Roe
Journal of Organic Chemistry, 1949 , vol. 14, p. 328,331
反应条件
hydrogenchloride; calcium chloride; sodium nitrite Erhitzen des Reaktionsprodukts mit Wasser;
参考文献
Hawkins; Roe
Journal of Organic Chemistry, 1949 , vol. 14, p. 328,331
