1-(4-氰基苄基)-1H-5-羟基甲基咪唑合成路线 (共 7 条)
反应条件
1: 94 percent / (COCl)2; DMF / acetonitrile / 3 h / 25 °C 2: 67 percent / iPr2EtN / acetonitrile / 0 - 23 °C View Scheme
参考文献
Maligres, Peter E.; Waters, Marjorie S.; Weissman, Steven A.; McWilliams, J. Christopher; Lewis, Stephanie; Cowen, Jennifer; Reamer, Robert A.; Volante; Reider, Paul J.; Askin, David
Journal of Heterocyclic Chemistry, 2003 , vol. 40, # 2 p. 229 - 241
反应条件
sodium hydroxide in methanol
T=20°C;
参考文献
Millet, Regis; Domarkas, Juozas; Houssin, Raymond; Gilleron, Pauline; Goossens, Jean-Francois; Chavatte, Philippe; Loge, Cedric; Pommery, Nicole; Pommery, Jean; Henichart, Jean-Pierre
Journal of Medicinal Chemistry, 2004 , vol. 47, # 27 p. 6812 - 6820
反应条件
sodium hydroxide; nitric acid; sodium nitrite in potassium thioisocyanate; water; acetic acid; isopropyl alcohol
参考文献
Casara, Patrick; Diguarher, Thierry Le; Dorey, Gilbert; Hickman, John; Pierre, Alain; Tucker, Gordon; Guilbaud, Nicolas
Patent: US2002/156113 A1, 2002 ;
反应条件
dihydrogen peroxide; acetic acid in water
T=35 - 45°C; caution exothermic; Product distribution; Further Variations:ReagentsTemperatures;
参考文献
Maligres, Peter E.; Waters, Marjorie S.; Weissman, Steven A.; McWilliams, J. Christopher; Lewis, Stephanie; Cowen, Jennifer; Reamer, Robert A.; Volante; Reider, Paul J.; Askin, David
Journal of Heterocyclic Chemistry, 2003 , vol. 40, # 2 p. 229 - 241
反应条件
1: ethyl acetate / 20 h / 60 °C
2: aq. LiOH / tetrahydrofuran / 1 h / 20 °C
View Scheme
参考文献
Li, Qun; Wang, Gary T.; Li, Tongmei; Gwaltney II, Stephen L.; Woods, Keith W.; Claiborne, Akiyo; Wang, Xilu; Gu, Wendy; Cohen, Jerry; Stoll, Vincent S.; Hutchins, Charles; Frost, David; Rosenberg, Saul H.; Sham, Hing L.
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 21 p. 5371 - 5376
反应条件
1: propionic acid / H2O; acetonitrile / 2 h / 60 °C
2: acetic acid; aq. H2O2 / 3 h / 20 °C
View Scheme
参考文献
Le Diguarher, Thierry; Ortuno, Jean-Claude; Dorey, Gilbert; Shanks, David; Guilbaud, Nicolas; Pierre, Alain; Fauchere, Jean-Luc; Hickman, John A.; Tucker, Gordon C.; Casara, Patrick J.
Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 14 p. 3193 - 3204
反应条件
triethylamine in dimethyl sulfoxide; ethyl acetate
参考文献
Merck and Co., Inc.
Patent: US5780488 A1, 1998 ;
Title/Abstract Full Text Show Details
Merck and Co., Inc.
Patent: US6063930 A1, 2000 ;
Title/Abstract Full Text Show Details
Merck and Co., Inc.
Patent: US5919785 A1, 1999 ;
US 5919785 A