1-(噻吩并[2,3-b]吡啶-5-基)乙酮合成路线 （共 5 条）
反应条件
1: 2-Nitrothiophene With hydrogenchloride; tin in water T=20 - 30°C; 2: With zinc(II) chloride in ethanol; water T=75°C; 1 h; 3: 4,4-dimethoxy-butan-2-one With sodium hydroxide more than 3 stages;
参考文献
Abbott Laboratories
Patent: US2008/153860 A1, 2008 ;
Location in patent: Page/Page column 24-25 ;
参考文献
Cazin, J.; Dupas, G.; Bourguignon, J.; Queguiner, G.
Tetrahedron Letters, 1986 , vol. 27, # 21 p. 2375 - 2378
反应条件
1: 71 percent / Br2, NaOH / H2O / 12 h / Ambient temperature 2: 1.) thionyle chloride; 2.) NH3 / 1.) reflux, 12 h; 2.) CH2Cl2, 0 deg C, 2 h 3: dimethylformamide / 8 h 4: 91 percent / sodium dithionite, sodium carbonate decahydrate / H2O / 0.25 h View Scheme
参考文献
Cazin, J.; Trefouel, T.; Dupas, G.; Bouguignon, J.; Queguiner, G.
Tetrahedron, 1988 , vol. 44, # 4 p. 1079 - 1090
反应条件
sulfur T=140°C; 17 h;
参考文献
Klemm,L.H.; Zell,R.
Journal of Heterocyclic Chemistry, 1968 , vol. 5, p. 773 - 778
反应条件
hydroxylamine in pyridine; ethanol T=80°C; 3 h;
参考文献
Abbott Laboratories
Patent: US2008/153860 A1, 2008 ;
Location in patent: Page/Page column 25 ;
