2-乙酰氧基-4-碘-1-甲氧基-苯合成路线 （共 12 条）
反应条件
1: With piperidine; copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride in tetrahydrofuran
T=20°C; Sonogashira-Linstrumelle coupling; 12 h;
2: With sodium hydroxide in methanol; water
T=20°C; 1 h;
参考文献
Provot, Olivier; Giraud, Anne; Peyrat, Jean-Francois; Alami, Mouad; Brion, Jean-Daniel
Tetrahedron Letters, 2005 , vol. 46, # 49 p. 8547 - 8550
反应条件
1.1: Pd(OAc)2; PPh3; Ag2CO3 / acetonitrile / Heating
1.2: mCPBA; aq. NaHCO3 / CH2Cl2
1.3: H2 / Pd/C
2.1: 98 percent / KOH / methanol
3.1: 100 percent / CuSO4 / benzene / Heating
View Scheme
参考文献
Lambert, Joshua D.; Rice, Joseph E.; Hong, Jungil; Hou, Zhe; Yang, Chung S.
Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 4 p. 873 - 876
