1-(3-溴-2-羟基苯基)乙酮合成路线 （共 10 条）
反应条件
N-bromosuccinmide; diisopropylamine in carbon disulfide T=0 - 20°C;
参考文献
Setoh, Masaki; Ishii, Naoki; Kono, Mitsunori; Miyanohana, Yuhei; Shiraishi, Eri; Harasawa, Toshiya; Ota, Hiroyuki; Odani, Tomoyuki; Kanzaki, Naoyuki; Aoyama, Kazunobu; Hamada, Teruki; Kori, Masakuni
Journal of Medicinal Chemistry, 2014 , vol. 57, # 12 p. 5226 - 5237
反应条件
Oxonereg;; NH4Br in methanol T=20°C; 4.5 h; regioselective reaction;
参考文献
Tetrahedron Letters, , vol. 53, # 2 p. 191 - 195
反应条件
1: With HNO2 Sandmeyer Reaction; 2: With copper(I) bromide
参考文献
SOLVAY PHARMACEUTICALS GMBH
Patent: WO2007/54580 A1, 2007 ;
Location in patent: Page/Page column 14 ;
反应条件
aluminium trichloride T=120°C;
参考文献
Monatshefte fuer Chemie, , vol. 96, p. 450 - 460
反应条件
1: acetic anhydride / Heating 2: AlCl3 / 120 °C View Scheme
参考文献
Monatshefte fuer Chemie, , vol. 96, p. 450 - 460
反应条件
N-bromosuccinmide T=80°C; 10 h; regioselective reaction;
参考文献
Journal of Organic Chemistry, , vol. 77, # 13 p. 5823 - 5828
反应条件
1: 3-bromo-2-hydroxyactophenone With lithium hexamethyldisilazane in tetrahydrofuran T=-78 - -20°C; 2.5 h; 2: benzoyl chloride in tetrahydrofuran T=-78 - 20°C; 3 h; 3: With sulfuric acid; acetic acid in tetrahydrofuran T=120°C; 0.0833333 h;
参考文献
Fitzmaurice, Richard J.; Etheridge, Zac C.; Jumel, Emelie; Woolfson, Derek N.; Caddick, Stephen
Chemical Communications, 2006 , # 46 p. 4814 - 4816
反应条件
1: pyrrolidine / methanol / 24 h / 20 °C
2: hydrogenchloride / ethyl acetate / 2 h / 20 °C
View Scheme
参考文献
Chaudhari, Sachin S.; Kadam, Ashok B.; Khairatkar-Joshi, Neelima; Mukhopadhyay, Indranil; Karnik, Pallavi V.; Raghuram, Anupindi; Rao, Shobha S.; Vaiyapuri, Thamil Selvan; Wale, Dinesh P.; Bhosale, Vikram M.; Gudi, Girish S.; Sangana, Ramchandra R.; Thomas, Abraham
Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 21 p. 6542 - 6553
反应条件
1.1: LHMDS / tetrahydrofuran / 2.5 h / -78 - -20 °C
1.2: tetrahydrofuran / 3 h / -78 - 20 °C
1.3: 75 percent / AcOH; H2SO4 / tetrahydrofuran / 0.08 h / 120 °C
2.1: 84 percent / POPd; CsF / tetrahydrofuran / 1.5 h / 85 °C / microwave irradiation
View Scheme
参考文献
Fitzmaurice, Richard J.; Etheridge, Zac C.; Jumel, Emelie; Woolfson, Derek N.; Caddick, Stephen
Chemical Communications, 2006 , # 46 p. 4814 - 4816
反应条件
1: N,N-dimethyl-formamide / 0.5 h / 70 - 75 °C
2: iodine / chloroform / 0.5 h / 20 °C
View Scheme
参考文献
Li, Gang; Zhang, Zun-Ting; Dai, Li-Yan; Du, Yin-Li; Xue, Dong
Helvetica Chimica Acta, 2012 , vol. 95, # 6 p. 989 - 997
