5-溴-n-甲氧基-n-甲基烟酰胺合成路线 （共 8 条）
反应条件
benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine in N,N-dimethyl-formamide T=20°C; 1 h;
参考文献
F. HOFFMANN-LA ROCHE AG; AEBI, Johannes; AMREIN, Kurt; HORNSPERGER, Benoit; KNUST, Henner; KUHN, Bernd; LIU, Yongfu; MAERKI, Hans P.; MAYWEG, Alexander V.; MOHR, Peter; TAN, Xuefei; ZHOU, Mingwei
Patent: WO2013/37779 A1, 2013 ;
Location in patent: Page/Page column 235 ;
反应条件
oxalyl dichloride; triethylamine in tetrahydrofuran T=0 - 20°C; 4 h;
参考文献
Galderma Research and Development, S.N.C.
Patent: US6706725 B1, 2004 ;
Location in patent: Page column 15-16 ;
反应条件
triethylamine in chloroform T=0 - 20°C; 1.58333 h;
参考文献
Romines, Karen R.; Freeman, George A.; Schaller, Lee T.; Cowan, Jill R.; Gonzales, Steve S.; Tidwell, Jeffrey H.; Andrews III, Clarence W.; Stammers, David K.; Hazen, Richard J.; Ferris, Robert G.; Short, Steven A.; Chan, Joseph H.; Boone, Lawrence R.
Journal of Medicinal Chemistry, 2006 , vol. 49, # 2 p. 727 - 739
反应条件
1: SOCl2 / 6 h / Heating 2: Et3N / CH2Cl2 / 24 h / 20 °C View Scheme
参考文献
Heterocycles, , vol. 53, # 10 p. 2183 - 2189
反应条件
in tetrahydrofuran T=-78 - 20°C; 2 h;
参考文献
F. HOFFMANN-LA ROCHE AG; AEBI, Johannes; AMREIN, Kurt; HORNSPERGER, Benoit; KNUST, Henner; KUHN, Bernd; LIU, Yongfu; MAERKI, Hans P.; MAYWEG, Alexander V.; MOHR, Peter; TAN, Xuefei; ZHOU, Mingwei
Patent: WO2013/37779 A1, 2013 ;
Location in patent: Page/Page column 235; 236 ;
反应条件
diisobutylaluminium hydride
参考文献
Heterocycles, , vol. 53, # 10 p. 2183 - 2189
反应条件
1.1: tetrahydrofuran / 2 h / -78 - 20 °C
2.1: titanium(IV) isopropylate; ammonia / methanol / |Reflux
2.2: 3 h / 0 - 20 °C
View Scheme
参考文献
F. HOFFMANN-LA ROCHE AG; AEBI, Johannes; AMREIN, Kurt; HORNSPERGER, Benoit; KNUST, Henner; KUHN, Bernd; LIU, Yongfu; MAERKI, Hans P.; MAYWEG, Alexander V.; MOHR, Peter; TAN, Xuefei; ZHOU, Mingwei
Patent: WO2013/37779 A1, 2013 ;
反应条件
1: in tetrahydrofuran; hexane
T=0°C; 3.5 h;
2: With hydrogenchloride; water in tetrahydrofuran; hexane
pH=1;
参考文献
Meiji Seika Kaisha, Ltd.
Patent: EP1661904 A1, 2006 ;
Location in patent: Page/Page column 47 ;
