1: potassium dihydrogenphosphate; phosphoric acid / water / 48 h / 98 °C / pH 4.1 / |Large scale 2: triethylamine; 4-(N,N-dimethlyamino)pyridine / tetrahydrofuran / 16 h / 0 - 25 °C / |Large scale 3: lithium aluminium tetrahydride; lithium iodide / toluene; tert-butyl methyl ether / 3 h / -30 °C / |Inert atmosphere; |Large scale 4: triethylamine; Pancreatin / tert-butyl methyl ether / 7 h / |Inert atmosphere; |Large scale; |Enzymatic reaction 5: hydrogen; 5 Pt/Al2O3 View Scheme

1: triethylamine; 4-(N,N-dimethlyamino)pyridine / tetrahydrofuran / 16 h / 0 - 25 °C / |Large scale 2: lithium aluminium tetrahydride; lithium iodide / toluene; tert-butyl methyl ether / 3 h / -30 °C / |Inert atmosphere; |Large scale 3: triethylamine; Pancreatin / tert-butyl methyl ether / 7 h / |Inert atmosphere; |Large scale; |Enzymatic reaction 4: hydrogen; 5 Pt/Al2O3 View Scheme

5 Pt/Al2O3; hydrogen Reagent/catalyst;