2-硝基-5-哌嗪-1-苯甲酸合成路线 （共 4 条）
反应条件
in neat (no solvent) T=110°C; 2 h;
参考文献
SANOFI-AVENTIS
Patent: WO2008/149168 A1, 2008 ;
Location in patent: Page/Page column 40-41 ;
WO 2008/149168 A1
反应条件
sodium hydroxide in 1,4-dioxane 16 h;
参考文献
Hutchinson, John H.; Cook, Jacquelynn J.; Brashear, Karen M.; Breslin, Michael J.; Glass, Joan D.; Gould, Robert J.; Halczenko, Wasyl; Holahan, Marie A.; Lynch, Robert J.; Sitko, Gary R.; Stranieri, Maria T.; Hartman, George D.
Journal of Medicinal Chemistry, 1996 , vol. 39, # 23 p. 4583 - 4591
反应条件
1: aq. NaOH / dioxane / 16 h 2: 3.1 g / HOBT, NMM, EDC / dimethylformamide / 16 h 3: H2 / 10percent Pd/C / ethanol / 3 h 4: 16 h / Heating View Scheme
参考文献
Hutchinson, John H.; Cook, Jacquelynn J.; Brashear, Karen M.; Breslin, Michael J.; Glass, Joan D.; Gould, Robert J.; Halczenko, Wasyl; Holahan, Marie A.; Lynch, Robert J.; Sitko, Gary R.; Stranieri, Maria T.; Hartman, George D.
Journal of Medicinal Chemistry, 1996 , vol. 39, # 23 p. 4583 - 4591
反应条件
1: aq. NaOH / dioxane / 16 h
2: 3.1 g / HOBT, NMM, EDC / dimethylformamide / 16 h
3: H2 / 10percent Pd/C / ethanol / 3 h
4: 16 h / Heating
5: aq. LiOH / methanol / Ambient temperature
View Scheme
参考文献
Hutchinson, John H.; Cook, Jacquelynn J.; Brashear, Karen M.; Breslin, Michael J.; Glass, Joan D.; Gould, Robert J.; Halczenko, Wasyl; Holahan, Marie A.; Lynch, Robert J.; Sitko, Gary R.; Stranieri, Maria T.; Hartman, George D.
Journal of Medicinal Chemistry, 1996 , vol. 39, # 23 p. 4583 - 4591
