N,4-二甲基-苯甲酰胺合成路线 （共 34 条）
反应条件
1: p-methyl-N-methylbenzamide With n-butyllithium in tetrahydrofuran; diethyl ether 0.5 h; Heating; 2: butanone in tetrahydrofuran; diethyl ether T=20°C; 3 h;
参考文献
Bhide; Kalaria; Panchal
Journal of Heterocyclic Chemistry, 2002 , vol. 39, # 4 p. 623 - 625
反应条件
sodium hydroxide; ethane-1,2-dial; copper dichloride Heating;
参考文献
Singh, Latika; Ram, Ram N.
Journal of Organic Chemistry, 1994 , vol. 59, # 4 p. 710 - 711
反应条件
1: 4-methyl-benzoic acid With oxalyl dichloride; N,N-dimethyl-formamide in dichloromethane
T=20°C; 5.5 h;
2: N-methylamine hydrochloride With triethylamine in dichloromethane
T=0 - 20°C; 1 h;
参考文献
TOYAMA CHEMICAL CO., LTD.; Hirono, Shuichi; Shiozawa, Shunichi
Patent: EP1445249 A1, 2004 ;
Location in patent: Page 138 ;
反应条件
1: 4-methyl-benzoic acid With thionyl chloride
T=80°C; 2 h;
2: methylamine in dichloromethane
T=20°C; Further stages.;
参考文献
Karimi, Farhad; Langstroem, Bengt
European Journal of Organic Chemistry, 2003 , # 11 p. 2132 - 2137
反应条件
copper(l) chloride in chlorobenzene
T=130°C; 12 h; Schlenk techniqueInert atmosphere;
参考文献
Xia, Qinqin; Liu, Xiaolong; Zhang, Yuejiao; Chen, Chao; Chen, Wanzhi
Organic Letters, 2013 , vol. 15, # 13 p. 3326 - 3329
反应条件
tris(2,4-di-tert-butyl-phenyl) phosphite; sodium methylate; [Ni(O2CCH3)2]*4H2O in diethylene glycol dimethyl ether
T=110°C; 10 h;
参考文献
Jo, Youngshin; Ju, Jinhun; Choe, Jaehoon; Kwang, Ho Song; Lee, Sunwoo
Journal of Organic Chemistry, 2009 , vol. 74, # 16 p. 6358 - 6361
反应条件
sodium hydroxide in water
0.25 h;
参考文献
Banks, Malcolm R.; Hudson, Robert F.
Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1986 , p. 1211 - 1216
反应条件
trifluoroacetic acid in acetonitrile
T=92°C; 0.166667 h; Inert atmosphereUV-irradiation; TemperatureReagent/catalystConcentrationTime;
参考文献
Zhang, Yuan; Blackman, Melissa L.; Leduc, Andrew B.; Jamison, Timothy F.
Angewandte Chemie - International Edition, 2013 , vol. 52, # 15 p. 4251 - 4255
Angew. Chem., 2013 , vol. 125, # 15 p. 4345 - 4349,5
反应条件
dicobalt octacarbonyl in benzene
T=180°C; P=56886.3 - 67229.2 Torr; stainless steel autoclave; Further byproducts given;
参考文献
Antebi, Shlomo; Alper, Howard
Canadian Journal of Chemistry, 1986 , vol. 64, p. 2010 - 2012
反应条件
tert.-butylhydroperoxide; copper(I) bromide in 1,2-dichloro-ethane
T=50°C; 3 h;
参考文献
Cheng, Dongping; Sun, Ruirui; Yan, Jizhong
Journal of Chemical Research, 2012 , vol. 36, # 4 p. 210 - 212
