2,2,2-三甲氧基乙酸甲酯合成路线 （共 16 条）
参考文献
Musser, J. H.; Hudec, T. T.; Bailey, K.
Synthetic Communications, 1984 , vol. 14, # 10 p. 947 - 954
参考文献
Musser, J. H.; Hudec, T. T.; Bailey, K.
Synthetic Communications, 1984 , vol. 14, # 10 p. 947 - 954
反应条件
1: With sodium hydride in tetrahydrofuran
T=65°C;
2: With hydrogenchloride in 1,4-dioxane
T=20°C;
参考文献
Jung, Jae-Kyu; Johnson, Benjamin R.; Duong, Tracy; Decaire, Marc; Uy, Jane; Gharbaoui, Tawfik; Boatman, P. Douglas; Sage, Carleton R.; Chen, Ruoping; Richman, Jeremy G.; Connolly, Daniel T.; Semple, Graeme
Journal of Medicinal Chemistry, 2007 , vol. 50, # 7 p. 1445 - 1448
反应条件
ammonia in water
Ambient temperature;
参考文献
Kantlehner, Willi; Kapassakalidis, Joannis J.; Maier, Thomas
Liebigs Annalen der Chemie, 1980 , # 9 p. 1448 - 1454
参考文献
Musser, J. H.; Hudec, T. T.; Bailey, K.
Synthetic Communications, 1984 , vol. 14, # 10 p. 947 - 954
反应条件
ytterbium(III) triflate in toluene
1.5 h; Heating / reflux;
参考文献
JANSSEN PHARMACEUTICA, N.V.
Patent: WO2004/22060 A2, 2004 ;
Location in patent: Page/Page column 43 ;
WO 2004/022060 A2
