1-N-Boc-3-哌嗪羧酸乙酯合成路线 （共 9 条）
反应条件
triethylamine in dichloromethane
参考文献
Pfizer Inc.
Patent: US6297380 B1, 2001 ;
反应条件
4-(N,N-dimethlyamino)pyridine in chloroform T=20°C; 15 h;
参考文献
Wyeth Holdings Corporation
Patent: EP1144368 B1, 2004 ;
Location in patent: Page 51 ;
反应条件
hydrogenchloride in dichloromethane T=0°C; 1 h;
参考文献
NEUROMED PHARMACEUTICALS LTD.
Patent: WO2007/71035 A1, 2007 ;
Location in patent: Page/Page column 44 ;
WO 2007/071035 A1
反应条件
potassium carbonate; triethylamine; palladium monocarbide in dichloromethane; acetic acid; toluene
参考文献
DAIICHI PHARMACEUTICAL CO., LTD.
Patent: EP1104754 A1, 2001 ;
反应条件
hydrogen; palladium on activated charcoal in ethanol 3 h;
参考文献
TANABE SEIYAKU CO., LTD.
Patent: EP1307455 B1, 2005 ;
Location in patent: Page/Page column 33 ;
反应条件
1.1: N,N-dimethyl-formamide / 24 h / 20 °C 2.1: sodium hydride / N,N-dimethyl-formamide / 0 - 20 °C 2.2: 6 h / 0 - 20 °C 3.1: hydrazine / ethanol / 0.33 h / |Reflux 4.1: dichloromethane / 20 °C / |Molecular sieve; |Inert atmosphere 5.1: 2,6-dimethylpyridine; copper(II) bis(trifluoromethanesulfonate) / dichloromethane / 12 h / 20 °C / |Inert atmosphere View Scheme
参考文献
Luescher, Michael U.; Vo, Cam-Van T.; Bode, Jeffrey W.
Organic Letters, 2014 , vol. 16, # 4 p. 1236 - 1239
反应条件
1.1: triethylamine / dichloromethane / 18 h / 0 - 20 °C 2.1: N,N-dimethyl-formamide / 24 h / 20 °C 3.1: sodium hydride / N,N-dimethyl-formamide / 0 - 20 °C 3.2: 6 h / 0 - 20 °C 4.1: hydrazine / ethanol / 0.33 h / |Reflux 5.1: dichloromethane / 20 °C / |Molecular sieve; |Inert atmosphere 6.1: 2,6-dimethylpyridine; copper(II) bis(trifluoromethanesulfonate) / dichloromethane / 12 h / 20 °C / |Inert atmosphere View Scheme
参考文献
Luescher, Michael U.; Vo, Cam-Van T.; Bode, Jeffrey W.
Organic Letters, 2014 , vol. 16, # 4 p. 1236 - 1239
反应条件
1.1: sodium hydride / N,N-dimethyl-formamide / 0 - 20 °C 1.2: 6 h / 0 - 20 °C 2.1: hydrazine / ethanol / 0.33 h / |Reflux 3.1: dichloromethane / 20 °C / |Molecular sieve; |Inert atmosphere 4.1: 2,6-dimethylpyridine; copper(II) bis(trifluoromethanesulfonate) / dichloromethane / 12 h / 20 °C / |Inert atmosphere View Scheme
参考文献
Luescher, Michael U.; Vo, Cam-Van T.; Bode, Jeffrey W.
Organic Letters, 2014 , vol. 16, # 4 p. 1236 - 1239
反应条件
lithium borohydride in tetrahydrofuran
参考文献
Himmelsbach, Frank; Langkopf, Elke; Jung, Birgit; Blech, Stefan; Solca, Flavia
Patent: US2002/49197 A1, 2002 ;
