(1,4-二苄基-2-哌嗪)-乙酸甲酯合成路线 （共 6 条）
反应条件
1: With methanol; sulfuric acid Heating / reflux; 2: With water; sodium hydrogencarbonate in methanol; dichloromethane pH=9;
参考文献
ARYX THERAPEUTICS, INC.
Patent: WO2008/112900 A1, 2008 ;
Location in patent: Page/Page column 61 ;
反应条件
hydrogenchloride; potassium carbonate; triethylamine in ethyl acetate; toluene
参考文献
DAIICHI PHARMACEUTICAL CO., LTD.
Patent: EP1104754 A1, 2001 ;
反应条件
triethylamine in toluene T=0 - 20°C; 48 h;
参考文献
ABBOTT LABORATORIES
Patent: US2011/288069 A1, 2011 ;
Location in patent: Page/Page column 39-40 ;
反应条件
hydrogenchloride; palladium monocarbide in methanol
参考文献
Berlex Laboratories, Inc.; Pharmacopeia, Inc.
Patent: US6432947 B1, 2002 ;
反应条件
1: aq. HCl; H2 / Pd/C / methanol / 24 h / 2585.74 Torr 2: 16.6 g / K2CO3 / tetrahydrofuran / 3 h / 0 - 20 °C / pH 9 - 10 View Scheme
参考文献
ABBOTT LABORATORIES
Patent: US2011/288069 A1, 2011 ;
反应条件
hydrogenchloride; hydrogen; palladium on activated charcoal in methanol
P=2585.74 Torr; 24 h;
参考文献
ARYX THERAPEUTICS, INC.
Patent: WO2008/112900 A1, 2008 ;
Location in patent: Page/Page column 61-62 ;
