3-(3-溴苯氧基)-丙酸合成路线 （共 8 条）
反应条件
1: With sulfuric acid in water; acetone T=0°C; 2: With chromium(VI) oxide T=0°C; 5 h;
参考文献
IPSEN PHARMA S.A.S.; ONCODESIGN S.A.; HOFLACK, Jan; BLOM, Petra
Patent: WO2013/46029 A1, 2013 ;
Location in patent: Page/Page column 80 ;
反应条件
1: 1-bromo-3-hydroxy-benzene With sodium hydride in N,N-dimethyl-formamide T=20°C; 1 h; Cooling with ice; 2: β-propiolactone in N,N-dimethyl-formamide T=20°C; 2 h; 3: With hydrogenchloride in water; N,N-dimethyl-formamide pH=3;
参考文献
Mochida Pharmaceutical Co., Ltd.
Patent: EP2518064 A1, 2012 ;
Location in patent: Page/Page column 42 ;
反应条件
sodium hydroxide in water
参考文献
Nikolic, Susanne; Bartel, Stephan; Brands, Michael; Niewohner, Ulrich; Paessens, Arnold; Graef, Erwin; Schlemmer, Karl-Heinz; Henninger, Kerstin; Endermann, Rainer; Weber, Olaf; Koletzki, Diana
Patent: US2002/82264 A1, 2002 ;
反应条件
hydrogenchloride; formic acid; water 24 h; Heating;
参考文献
Patonay, Tams; Vasas, Attila; Kiss-Szikszai, Attila; Silva, Artur M. S.; Cavaleiro, Jos A. S.
Australian Journal of Chemistry, 2010 , vol. 63, # 11 p. 1582 - 1593
反应条件
1: N-benzyl-trimethylammonium hydroxide / methanol / Heating 2: hydrogenchloride; formic acid; water / 24 h / Heating View Scheme
参考文献
IPSEN PHARMA S.A.S.; ONCODESIGN S.A.; HOFLACK, Jan; BLOM, Petra
Patent: WO2013/46029 A1, 2013 ;
反应条件
1: 1 h; Heating; 2: With iodine in dimethyl sulfoxide 2 h; Reflux;
参考文献
Australian Journal of Chemistry, , vol. 63, # 11 p. 1582 - 1593
反应条件
polyphosphoric acid 1 h; Heating;
参考文献
Mochida Pharmaceutical Co., Ltd.
Patent: EP2518064 A1, 2012 ;
Location in patent: Page/Page column 42 ;
反应条件
phosphorus pentachloride; aluminium chloride
参考文献
Nikolic, Susanne; Bartel, Stephan; Brands, Michael; Niewohner, Ulrich; Paessens, Arnold; Graef, Erwin; Schlemmer, Karl-Heinz; Henninger, Kerstin; Endermann, Rainer; Weber, Olaf; Koletzki, Diana
Patent: US2002/82264 A1, 2002 ;
