4-N-甲基吡啶-3,4-二胺合成路线 （共 13 条）
反应条件
hydrogen; palladium 10 on activated carbon in methanol T=20°C; 21 h;
参考文献
PFIZER PRODUCTS INC.
Patent: WO2008/12622 A2, 2008 ;
Location in patent: Page/Page column 55-56 ;
WO 2008/012622 A2
反应条件
1: 59 percent / ethanol / 0.33 h / 0 °C 2: H2 / 5percent Pd/C / ethanol View Scheme
参考文献
BIOMARIN PHARMACEUTICAL INC.; WANG, Bing; CHU, Daniel
Patent: WO2011/130661 A1, 2011 ;
反应条件
1: methylamine / ethanol; water 2: raney Nickel / methanol View Scheme
参考文献
BOEHRINGER INGELHEIM INTERNATIONAL GMBH; Nickolaus, Peter
Patent: US2013/225609 A1, 2013 ;
参考文献
Cheil Foods and Chemicals, Inc.
Patent: US5281589 A1, 1994 ;
反应条件
methylamine in trichlorophosphate
参考文献
Burroughs Wellcome Co.
Patent: US4603139 A1, 1986 ;
反应条件
sulfur
T=150°C; 5 h;
参考文献
Yutilov, Yu. M.; Shcherbina, L. I.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1987 , vol. 23, # 5 p. 529 - 535
Khimiya Geterotsiklicheskikh Soedinenii, 1987 , vol. 23, # 5 p. 639 - 645
反应条件
sulfur
T=185 - 200°C; 10 h;
参考文献
Yutilov, Yu. M.; Shcherbina, L. I.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1987 , vol. 23, # 5 p. 529 - 535
Khimiya Geterotsiklicheskikh Soedinenii, 1987 , vol. 23, # 5 p. 639 - 645
参考文献
BIOMARIN PHARMACEUTICAL INC.; WANG, Bing; CHU, Daniel
Patent: WO2011/130661 A1, 2011 ;
Location in patent: Page/Page column 173 ;
反应条件
ethanol; copper diacetate
T=150°C;
参考文献
Weidenhagen; Train
Chemische Berichte, 1942 , vol. 75, p. 1936,1942
参考文献
Katner; Brown
Journal of Heterocyclic Chemistry, 1990 , vol. 27, # 3 p. 563 - 566
