(S)-(+)-N-(叔丁氧羰基)-2-甲基哌啶合成路线 （共 13 条）
反应条件
methoxybenzene; trifluoroacetic acid in dichloromethane Decarboxylation;
参考文献
Bois; Gardette; Gramain
Tetrahedron Letters, 2000 , vol. 41, # 45 p. 8769 - 8772
反应条件
sodium hydroxide in tetrahydrofuran
16 h; Ambient temperature;
参考文献
Adamo, Mauro F. A.; Aggarwal, Varinder K.; Sage, Matthew A.
Synthetic Communications, 1999 , vol. 29, # 10 p. 1747 - 1756
参考文献
Chackalamannil, Samuel; Davies, Robert J.; Asberom, Theodros; Doller, Dario; Leone, Daria
Journal of the American Chemical Society, 1996 , vol. 118, # 40 p. 9812 - 9813
反应条件
triethylamine in tetrahydrofuran
参考文献
Tchabanenko, Kirill; Adlington, Robert M.; Cowley, Andrew R.; Baldwin, Jack E.
Organic Letters, 2005 , vol. 7, # 4 p. 585 - 588
Title/Abstract Full Text View citing articles Show Details
Tchabanenko, Kirill; Chesworth, Richard; Parker, Jeremy S.; Anand, Neel K.; Russell, Andrew T.; Adlington, Robert M.; Baldwin, Jack E.
Tetrahedron, 2005 , vol. 61, # 49 p. 11649 - 11656
反应条件
1: L-tartaric acid
2: Et3N / tetrahydrofuran
View Scheme
参考文献
Tchabanenko, Kirill; Adlington, Robert M.; Cowley, Andrew R.; Baldwin, Jack E.
Organic Letters, 2005 , vol. 7, # 4 p. 585 - 588
反应条件
1: 1-(tert-butoxy-carbonyl)piperidine With N,N,N',N,-tetramethylethylenediamine; sec.-butyllithium in diethyl ether; hexane
T=-78°C;
2: With C13H28N2O; sec.-butyllithium in diethyl ether; hexane
T=-78 - -30°C;
3: methyl iodide in diethyl ether; hexane
T=-78 - 20°C; 18 h; optical yield given as percent eeenantioselective reaction;
参考文献
Coldham, Iain; Raimbault, Sophie; Whittaker, David T. E.; Chovatia, Praful T.; Leonori, Daniele; Patel, Jignesh J.; Sheikh, Nadeem S.
Chemistry - A European Journal, 2010 , vol. 16, # 13 p. 4082 - 4090
反应条件
1: 1-(tert-butoxy-carbonyl)piperidine With N,N,N',N,-tetramethylethylenediamine; sec.-butyllithium in diethyl ether; hexane
T=-78°C;
2: With C13H28N2O; sec.-butyllithium in diethyl ether; hexane
T=-78 - -30°C;
3: dimethyl sulfate in diethyl ether; hexane
T=-78 - 20°C; 18 h; optical yield given as percent eeenantioselective reaction;
参考文献
Coldham, Iain; Raimbault, Sophie; Whittaker, David T. E.; Chovatia, Praful T.; Leonori, Daniele; Patel, Jignesh J.; Sheikh, Nadeem S.
Chemistry - A European Journal, 2010 , vol. 16, # 13 p. 4082 - 4090
反应条件
1: N-Boc-2-(tributylstannyl)piperidine With n-butyllithium in tetrahydrofuran; hexanes
T=-78°C; Inert atmosphere;
2: dimethyl sulfate in tetrahydrofuran; hexanes
T=-78 - 20°C; Inert atmosphere; optical yield given as percent ee;
参考文献
Stead, Darren; Carbone, Giorgio; O'Brien, Peter; Campos, Kevin R.; Coldham, Iain; Sanderson, Adam
Journal of the American Chemical Society, 2010 , vol. 132, # 21 p. 7260 - 7261
反应条件
1: NaBH4 / benzene; toluene; methanol / Irradiation
2: 91 percent / LiAlH4 / tetrahydrofuran / Heating
3: H2; Pd(OH)2 / methanol
View Scheme
参考文献
Bois; Gardette; Gramain
Tetrahedron Letters, 2000 , vol. 41, # 45 p. 8769 - 8772
反应条件
1: 91 percent / LiAlH4 / tetrahydrofuran / Heating
2: H2; Pd(OH)2 / methanol
View Scheme
参考文献
Bois; Gardette; Gramain
Tetrahedron Letters, 2000 , vol. 41, # 45 p. 8769 - 8772
