(S)-(+)-N-(叔丁氧羰基)-2-甲基哌啶合成路线 （共 13 条）
反应条件
palladium dihydroxide; hydrogen in methanol
Acylation;
参考文献
Bois; Gardette; Gramain
Tetrahedron Letters, 2000 , vol. 41, # 45 p. 8769 - 8772
反应条件
Multistep reaction.;
参考文献
Coldham, Iain; Patel, Jignesh J.; Raimbault, Sophie; Whittaker, David T. E.
Chemical Communications, 2007 , # 43 p. 4534 - 4536
反应条件
1.1: 39 percent / RuO4; NaIO4 / ethyl acetate; H2O
2.1: 54 percent / n-BuLi / tetrahydrofuran; hexane / -78 - 20 °C
3.1: 50 percent / LiCl; (i-Pr)2EtN / acetonitrile / 12 h
4.1: TFA / CH2Cl2 / 0 - 20 °C
4.2: NaCNBH3 / CH2Cl2; ethanol / 0.01 h / 20 °C
4.3: aq. NaHCO3 / CH2Cl2; ethanol / 20 °C
5.1: Et3N / CH2Cl2 / 14 h
6.1: 11 percent / H2 / PtO2 / ethanol / 12 h
7.1: 95 percent / TFA / CH2Cl2 / 1 h
8.1: 74 percent / sodium cyanoborohydride / acetonitrile; H2O / 1 h / 20 °C
View Scheme
参考文献
Chackalamannil, Samuel; Davies, Robert J.; Wang, Yuguang; Asberom, Theodros; Doller, Dario; Wong, Jesse; Leone, Daria; McPhail, Andrew T.
Journal of Organic Chemistry, 1999 , vol. 64, # 6 p. 1932 - 1940
