阿尔法,阿尔法,阿尔法位-三氟-间-甲苯异硫氰合成路线 （共 16 条）
反应条件
1: With 1,4-diaza-bicyclo[2.2.2]octane in toluene T=20°C; 8 h; 2: With bis(trichloromethyl) carbonate in dichloromethane T=-5°C; Reflux;
参考文献
Bioorganic and Medicinal Chemistry, , vol. 20, # 9 p. 2923 - 2929
反应条件
triethylamine in tetrahydrofuran T=0 - 20°C; 2.5 h; Inert atmosphere;
参考文献
Tetrahedron Letters, , vol. 52, # 50 p. 6719 - 6722
反应条件
1: sodium hydride / tetrahydrofuran; various solvent(s) / 20 h / Heating 2: 41 percent / tosyl chloride; triethylamine / tetrahydrofuran / 1 h / 22 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 72, # 10 p. 3969 - 3971
反应条件
hydrogenchloride; tin(ll) chloride in chloroform
参考文献
Journal of the Chemical Society [Section] C: Organic, , p. 2471 - 2472
反应条件
in dichloromethane T=20°C; 2 h;
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 22, # 12 p. 3916 - 3920
反应条件
in chlorobenzene Heating;
参考文献
Tetrahedron, , vol. 19, p. 1603 - 1610
反应条件
acetic anhydride 1 h; Reflux;
参考文献
Bioorganic and Medicinal Chemistry, , vol. 17, # 4 p. 1437 - 1444
反应条件
1.1: triethylamine / water; tetrahydrofuran / 3.5 h / 0 - 20 °C 1.2: Reflux 2.1: piperidine / ethanol / 2 h / Reflux View Scheme
参考文献
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Patent: US2011/105565 A1, 2011 ;
反应条件
hydrazine hydrate in ethanol T=20°C; 2 h;
参考文献
Liu, Wen-Xia; Yang, Rui; Li, Ai-Fang; Li, Zhao; Gao, Yu-Feng; Luo, Xing-Xing; Ruan, Yi-Bin; Jiang, Yun-Bao
Organic and Biomolecular Chemistry, 2009 , vol. 7, # 19 p. 4021 - 4028
反应条件
in ethanol 0.5 h; Heating;
参考文献
Blumenkopf; Harrington; Koble; Bankston; Morrison Jr.; Bigham; Styles; Spector
Journal of Medicinal Chemistry, 1992 , vol. 35, # 12 p. 2306 - 2314
