3-(N-(4-氯-3-甲基异噁唑-5-基)磺酰基)噻吩-2-羧酸合成路线 （共 5 条）
参考文献
Texas Biotechnology Corp.
Patent: US6342610 B2, 2002 ;
Location in patent: Page column 100 ;
US 6342610 B2
反应条件
1: NaH / tetrahydrofuran / 1 h / Ambient temperature 2: aq. NaOH / 8 h / Ambient temperature View Scheme
参考文献
Eisai RandD Management Co., Ltd.; Tanaka, Keigo; Nishioka, Tomoki
Patent: US2013/197045 A1, 2013 ;
反应条件
1: 3{[(4-chloro-3-methyl-5-isoxazolyl)amino]sulfonyl}-2-thiophenecarboxylic acid With 1,1'-carbonyldiimidazole in tetrahydrofuran T=20°C; 0.5 h; 2: O,N-dimethyl-hydroxylamine hydrochloride With 1H-imidazole in tetrahydrofuran T=20°C; 5 h;
参考文献
Eisai RandD Management Co., Ltd.; Tanaka, Keigo; Nishioka, Tomoki
Patent: US2013/197045 A1, 2013 ;
Location in patent: Paragraph 0140; 0141; 0142 ;
参考文献
Texas Biotechnology Corp.
Patent: US6342610 B2, 2002 ;
Location in patent: Page column 126 ;
US 6342610 B2
参考文献
Texas Biotechnology Corp.
Patent: US6342610 B2, 2002 ;
Location in patent: Page column 129 ;
US 6342610 B2
