(2S,3S)-3-羟基-1,2-吡咯烷二羧酸 1-叔丁酯 2-甲基酯合成路线 （共 13 条）
反应条件
sodium hydrogencarbonate in tetrahydrofuran; water T=0 - 20°C; Inert atmosphereCooling with ice bath;
参考文献
ACHAOGEN, INC.
Patent: WO2009/137130 A2, 2009 ;
Location in patent: Page/Page column 146-147 ;
反应条件
potassium carbonate in N,N-dimethyl-formamide T=0 - 90°C; 2 h;
参考文献
TETRALOGIC PHARMACEUTICALS CORP.; CONDON, Stephen, M.; LAPORTE, Matthew, G.
Patent: WO2010/33531 A1, 2010 ;
Location in patent: Page/Page column 66 ;
反应条件
triethylamine in 1,4-dioxane
参考文献
DAIICHI PHARMACEUTICAL CO., LTD.
Patent: EP1757602 A1, 2007 ;
反应条件
1: 80 percent / aq. NaOH / tetrahydrofuran 2: diethyl ether View Scheme
参考文献
Sun, Chong-Qing; Hamann, Lawrence; Augeri, David; Bi, Yingzhi; Robl, Jeffrey; Huang, Yan-Ting; Wang, Tammy; Holubec, Alexandra; Simpkins, Ligaya; Sutton, James C.; Li, James J.
Patent: US2004/181064 A1, 2004 ;
US 20040181064 A1
反应条件
1: 99 percent / HCl / 0 - 20 °C 2: 80 percent / Et3N / CH2Cl2 / 0 - 20 °C View Scheme
参考文献
Gomez-Vidal, Jose A.; Silverman, Richard B.
Organic Letters, 2001 , vol. 3, # 16 p. 2481 - 2484
反应条件
in methanol; diethyl ether T=20°C; 0.25 h;
参考文献
Gomez-Vidal, Jose A.; Silverman, Richard B.
Organic Letters, 2001 , vol. 3, # 16 p. 2481 - 2484
反应条件
triethylamine in dichloromethane
参考文献
Napolitano, Carmela; Borriello, Manuela; Cardullo, Francesca; Donati, Daniele; Paio, Alfredo; Manfredini, Stefano
Tetrahedron Letters, 2009 , vol. 50, # 52 p. 7280 - 7282
反应条件
in tetrahydrofuran; methanol; diethyl ether T=0°C; 2 h; Product distribution / selectivity;
参考文献
Vicuron Pharmaceuticals Inc.
Patent: US2010/22605 A1, 2010 ;
Location in patent: Page/Page column 16; 33; 36 ;
US 20100022605 A1
反应条件
1: 88 percent / triethylamine / dioxane; H2O; methanol / 4 h / 20 °C 2: 99 percent / methanol; diethyl ether / 0.25 h / 20 °C View Scheme
参考文献
Gomez-Vidal, Jose A.; Silverman, Richard B.
Organic Letters, 2001 , vol. 3, # 16 p. 2481 - 2484
反应条件
1: PPh3P; diisopropyl azodicarboxylate / tetrahydrofuran / 3 h 2: aq. NaOH / tetrahydrofuran / 1 h View Scheme
参考文献
Hodges, Jonathan A.; Raines, Ronald T.
Journal of the American Chemical Society, 2005 , vol. 127, # 45 p. 15923 - 15932
