1: 3-hydroxymethyl-1-chlorobenzene With trifluoromethylsulfonic anhydride; bis-(phenyl)-sulfoxide; N,N,N',N'-tetra-methylnaphthalene-1,8-diamine in toluene
T=-78°C;
2: sodium salt of dimethylmalonate in tetrahydrofuran; toluene
T=-78 - 20°C;
参考文献
Takuwa, Tomofumi; Minowa, Tomofumi; Fujisawa, Hidehiko; Mukaiyama, Teruaki
Chemical and Pharmaceutical Bulletin, 2005 , vol. 53, # 5 p. 476 - 480
1: (2-chlorophenyl)methanol With trifluoromethylsulfonic anhydride; bis-(phenyl)-sulfoxide; N,N,N',N'-tetra-methylnaphthalene-1,8-diamine in toluene
T=-78°C;
2: sodium salt of dimethylmalonate in tetrahydrofuran; toluene
T=-78 - 20°C;
参考文献
Takuwa, Tomofumi; Minowa, Tomofumi; Fujisawa, Hidehiko; Mukaiyama, Teruaki
Chemical and Pharmaceutical Bulletin, 2005 , vol. 53, # 5 p. 476 - 480
1: 2-hydroxymethyl-1-methyl-1H-indole With n-butyllithium; methanesulfonyl chloride; lithium bromide in tetrahydrofuran
Inert atmosphere;
2: sodium salt of dimethylmalonate Inert atmosphere;
参考文献
Huang, Haoxi; Peters, Rene
Angewandte Chemie - International Edition, 2009 , vol. 48, # 3 p. 604 - 606
1: 4-chloro-1-hydroxymethyl-benzene With trifluoromethylsulfonic anhydride; bis-(phenyl)-sulfoxide; N,N,N',N'-tetra-methylnaphthalene-1,8-diamine in toluene
T=-78°C;
2: sodium salt of dimethylmalonate in tetrahydrofuran; toluene
T=-78 - 20°C;
参考文献
Takuwa, Tomofumi; Minowa, Tomofumi; Fujisawa, Hidehiko; Mukaiyama, Teruaki
Chemical and Pharmaceutical Bulletin, 2005 , vol. 53, # 5 p. 476 - 480
1: benzyl alcohol With trifluoromethylsulfonic anhydride; bis-(phenyl)-sulfoxide; N,N,N',N'-tetra-methylnaphthalene-1,8-diamine in toluene
T=-78°C; 1 h;
2: sodium salt of dimethylmalonate in tetrahydrofuran; toluene
T=-78 - 20°C;
参考文献
Takuwa, Tomofumi; Minowa, Tomofumi; Fujisawa, Hidehiko; Mukaiyama, Teruaki
Chemical and Pharmaceutical Bulletin, 2005 , vol. 53, # 5 p. 476 - 480
1: (4-methylphenyl)methyl alcohol With trifluoromethylsulfonic anhydride; bis-(phenyl)-sulfoxide; N,N,N',N'-tetra-methylnaphthalene-1,8-diamine in toluene
T=-78°C;
2: sodium salt of dimethylmalonate in tetrahydrofuran; toluene
T=-78 - 20°C;
参考文献
Takuwa, Tomofumi; Minowa, Tomofumi; Fujisawa, Hidehiko; Mukaiyama, Teruaki
Chemical and Pharmaceutical Bulletin, 2005 , vol. 53, # 5 p. 476 - 480
