(4S)-(-)-异丙基-5,5-二苯基-2-恶唑烷酮合成路线 （共 35 条）
反应条件
1: T=20°C; Cooling with ice; 2: With hydrogenchloride in methanol; water
参考文献
EP2103603 A1, ;
Page/Page column 97 ;
EP 2103603 A1
反应条件
potassium hydroxide in toluene
参考文献
Alexander; Cook; Gibson; Kennedy
Journal of the Chemical Society. Perkin Transactions 1, 2001 , # 13 p. 1538 - 1549
反应条件
lithium hydroxide; dihydrogen peroxide in tetrahydrofuran; water T=0°C; 1.5 h;
参考文献
Helvetica Chimica Acta, , vol. 81, # 11 p. 2093 - 2126
反应条件
n-butyllithium in tetrahydrofuran T=0°C; 2 h;
参考文献
Helvetica Chimica Acta, , vol. 81, # 11 p. 2093 - 2126
反应条件
triethylamine in tetrahydrofuran; toluene 2 h;
参考文献
Gawley, Robert E.; Zhang, Pingsheng
Journal of Organic Chemistry, 1996 , vol. 61, # 23 p. 8103 - 8112
反应条件
1: (S)-3-[(1S,2R,4R)-4-[(benzyloxy)methoxy]-1-(methylsulfanyl)-2,4-diphenylbutyl]-4-isopropyl-5,5-diphenyloxazolidin-2-one With mercury(II) trifluoroacetate in tetrahydrofuran; water; acetonitrile T=20°C; 0.0833333 h; 2: methyl-magnesium chloride in tetrahydrofuran T=-78°C; 0.166667 h;
参考文献
Gaul, Christoph; Seebach, Dieter
Helvetica Chimica Acta, 2002 , vol. 85, # 3 p. 772 - 787
反应条件
lithium hydroxide; dihydrogen peroxide in tetrahydrofuran T=-10 - 0°C;
参考文献
Tetrahedron Asymmetry, , vol. 18, # 8 p. 949 - 962
反应条件
lithium hydroxide; dihydrogen peroxide in tetrahydrofuran T=-10 - 0°C;
参考文献
Tetrahedron Asymmetry, , vol. 18, # 8 p. 949 - 962
反应条件
1.1: BuLi / tetrahydrofuran / 0.08 h / -78 °C 1.2: 83 percent / tetrahydrofuran / 0.17 h / -78 °C 2.1: Hg(O2CCF3)2 / tetrahydrofuran; acetonitrile; H2O / 0.08 h / 20 °C 2.2: 72 percent / NaBH4; DBU / tetrahydrofuran; H2O / 0.25 h View Scheme
参考文献
Helvetica Chimica Acta, , vol. 85, # 3 p. 772 - 787
反应条件
1,8-diazabicyclo[5.4.0]undec-7-ene; lithium bromide in tetrahydrofuran 4 h; Ambient temperature;
参考文献
Helvetica Chimica Acta, , vol. 81, # 11 p. 2093 - 2126
