(4S)-(-)-异丙基-5,5-二苯基-2-恶唑烷酮合成路线 （共 35 条）
反应条件
1.1: Mg / tetrahydrofuran 1.2: 54 percent / tetrahydrofuran / 4 h / 20 °C 2.1: 73 percent / aq. KOH / toluene / 2 h / 20 °C View Scheme
参考文献
Journal of the Chemical Society. Perkin Transactions 1, , # 13 p. 1538 - 1549
反应条件
1.1: Noyori catalyst (S,S) / CH2Cl2; propan-2-ol / 96 h / 20 °C 2.1: 95 percent / DMAP / CH2Cl2 / 0.17 h / 20 °C 3.1: Hg(O2CCF3)2 / tetrahydrofuran; acetonitrile; H2O / 0.08 h / 20 °C 3.2: DBU; NaBH4 / tetrahydrofuran; H2O View Scheme
参考文献
Helvetica Chimica Acta, , vol. 85, # 3 p. 772 - 787
反应条件
1.1: diethyl zinc / Ni(acac)2 / CH2Cl2; hexane / 0.5 h / 0 °C 1.2: CH2Cl2; hexane / -30 °C 2.1: 74.1 percent / aq. H2O2; LiOH*H2O / tetrahydrofuran / -10 - 0 °C View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 18, # 8 p. 949 - 962
反应条件
1: iPrNEt / CH2Cl2 2: Hg(O2CCF3)2; H2O / acetonitrile; tetrahydrofuran / 0.08 h / 20 °C 3: DBU; NaBH4 / tetrahydrofuran; H2O / 0 °C View Scheme
参考文献
Organic Letters, , vol. 2, # 11 p. 1501 - 1504
反应条件
1: Hg(O2CCF3)2; H2O / acetonitrile; tetrahydrofuran / 0.08 h / 20 °C 2: DBU; NaBH4 / tetrahydrofuran; H2O / 0.25 h / 0 °C View Scheme
参考文献
Organic Letters, , vol. 2, # 11 p. 1501 - 1504
反应条件
1: Hg(O2CCF3)2; H2O / acetonitrile; tetrahydrofuran / 0.08 h / 20 °C 2: DBU; NaBH4 / tetrahydrofuran; H2O / 0 °C View Scheme
参考文献
Organic Letters, , vol. 2, # 11 p. 1501 - 1504
反应条件
1: Hg(O2CCF3)2; H2O / acetonitrile; tetrahydrofuran / 0.08 h / 20 °C 2: DBU; NaBH4 / tetrahydrofuran; H2O / 0 °C View Scheme
参考文献
Organic Letters, , vol. 2, # 11 p. 1501 - 1504
反应条件
lithium hydroxide Yield given;
参考文献
Gibson, Colin L.; Gillon, Karen; Cook, Stuart
Tetrahedron Letters, 1998 , vol. 39, # 37 p. 6733 - 6736
反应条件
lithium hydroxide Yield given;
参考文献
Gibson, Colin L.; Gillon, Karen; Cook, Stuart
Tetrahedron Letters, 1998 , vol. 39, # 37 p. 6733 - 6736
反应条件
1: With mercury(II) trifluoroacetate in tetrahydrofuran; water; acetonitrile T=20°C; 0.0833333 h; 2: With sodium tetrahydroborate; 1,8-diazabicyclo[5.4.0]undec-7-ene in tetrahydrofuran; water
参考文献
Helvetica Chimica Acta, , vol. 85, # 3 p. 772 - 787
