(4S)-(-)-异丙基-5,5-二苯基-2-恶唑烷酮合成路线 （共 35 条）
反应条件
1: 1.)LDA, ZnBr2 / 1.)THF, -78 deg C, 60 min; 2.)THF, -15 deg C, 24 h 2: 92 percent / LiBr, DBU / tetrahydrofuran / 4 h / Ambient temperature View Scheme
参考文献
Helvetica Chimica Acta, , vol. 81, # 11 p. 2093 - 2126
反应条件
1: With mercury(II) trifluoroacetate in tetrahydrofuran; water; acetonitrile T=20°C; 0.0833333 h; 2: With sodium tetrahydroborate; 1,8-diazabicyclo[5.4.0]undec-7-ene in tetrahydrofuran; water
参考文献
Helvetica Chimica Acta, , vol. 85, # 3 p. 772 - 787
反应条件
1: bromobenzene With magnesium 2: methyl (S)-2-[(ethoxycarbonyl)amino]-3-methylbutanoate in tetrahydrofuran T=0 - 20°C; 3: With sodium hydroxide in tetrahydrofuran T=0°C; 3 h; Further stages.;
参考文献
Yu, Luo-Ting; Ho, Meng-Tsung; Chang, Ching-Yao; Yang, Teng-Kuei
Tetrahedron Asymmetry, 2007 , vol. 18, # 8 p. 949 - 962
反应条件
1: 1) Mg / 1) THF, reflux, 1 h, 2) THF, room temperature, overnight 2: 95 percent / Et3N / tetrahydrofuran; toluene / 2 h View Scheme
参考文献
Journal of Organic Chemistry, , vol. 61, # 23 p. 8103 - 8112
反应条件
sulfuric acid in chloroform T=20°C; 336 h;
参考文献
Helvetica Chimica Acta, , vol. 85, # 3 p. 772 - 787
反应条件
1.1: 95 percent / DMAP / CH2Cl2 / 0.17 h / 20 °C 2.1: Hg(O2CCF3)2 / tetrahydrofuran; acetonitrile; H2O / 0.08 h / 20 °C 2.2: DBU; NaBH4 / tetrahydrofuran; H2O View Scheme
参考文献
Helvetica Chimica Acta, , vol. 85, # 3 p. 772 - 787
反应条件
1: 54 percent 2: 73 percent / KOH / toluene View Scheme
参考文献
Tetrahedron Letters, , vol. 39, # 37 p. 6733 - 6736
反应条件
1: diethyl ether / 9 h / Heating 2: Et3N / CH2Cl2 / -25 - 0 °C 3: NaOH / methanol / 9 h / Heating View Scheme
参考文献
Helvetica Chimica Acta, , vol. 81, # 11 p. 2093 - 2126
反应条件
1: Et3N / CH2Cl2 / -25 - 0 °C 2: NaOH / methanol / 9 h / Heating View Scheme
参考文献
Helvetica Chimica Acta, , vol. 81, # 11 p. 2093 - 2126
反应条件
1.1: Mg / tetrahydrofuran 1.2: 54 percent / tetrahydrofuran / 4 h / 20 °C 2.1: 73 percent / aq. KOH / toluene / 2 h / 20 °C View Scheme
参考文献
Journal of the Chemical Society. Perkin Transactions 1, , # 13 p. 1538 - 1549
