N4-(3-氯-4-氟苯基)-4,6-喹唑啉二胺合成路线 （共 7 条）
反应条件
hydrogen; nickel in tetrahydrofuran; methanol P=2585.74 Torr; 3.5 h;
参考文献
Fernandes, Celia; Oliveira, Cristina; Gano, Lurdes; Bourkoula, Athanasia; Pirmettis, Ioannis; Santos, Isabel
Bioorganic and Medicinal Chemistry, 2007 , vol. 15, # 12 p. 3974 - 3980
反应条件
1: 96.9 percent / 1.5 h / 100 °C 2: 77.3 percent / AcOH / 1 h / Heating 3: 30.9 percent / iron; AcOH / ethanol / 3 h / Heating View Scheme
参考文献
Marvania, Bhavin; Lee, Pei-Chih; Chaniyara, Ravi; Dong, Huajin; Suman, Sharda; Kakadiya, Rajesh; Chou, Ting-Chao; Lee, Te-Chang; Shah, Anamik; Su, Tsann-Long
Bioorganic and Medicinal Chemistry, 2011 , vol. 19, # 6 p. 1987 - 1998
反应条件
1: 7 h / 130 °C 2: nitric acid; sulfuric acid / 0.67 h / 95 °C 3: thionyl chloride / 3 h / |Reflux 4: isopropyl alcohol / 2 h / |Reflux 5: acetic acid; iron / ethanol; water / 1.5 h / 95 °C View Scheme
参考文献
Aberg, Ola; Langstroema, Bengt
Journal of Labelled Compounds and Radiopharmaceuticals, 2012 , vol. 55, # 14 p. 477 - 483
反应条件
1: nitric acid; sulfuric acid / 0.67 h / 95 °C 2: thionyl chloride / 3 h / |Reflux 3: isopropyl alcohol / 2 h / |Reflux 4: acetic acid; iron / ethanol; water / 1.5 h / 95 °C View Scheme
参考文献
Aberg, Ola; Langstroema, Bengt
Journal of Labelled Compounds and Radiopharmaceuticals, 2012 , vol. 55, # 14 p. 477 - 483
反应条件
1: thionyl chloride / 3 h / |Reflux 2: isopropyl alcohol / 2 h / |Reflux 3: acetic acid; iron / ethanol; water / 1.5 h / 95 °C View Scheme
参考文献
Aberg, Ola; Langstroema, Bengt
Journal of Labelled Compounds and Radiopharmaceuticals, 2012 , vol. 55, # 14 p. 477 - 483
反应条件
1: isopropyl alcohol / 2 h / |Reflux 2: acetic acid; iron / ethanol; water / 1.5 h / 95 °C View Scheme
参考文献
Aberg, Ola; Langstroema, Bengt
Journal of Labelled Compounds and Radiopharmaceuticals, 2012 , vol. 55, # 14 p. 477 - 483
反应条件
in tetrahydrofuran; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide
参考文献
Zeneca Limited
Patent: US6015814 A1, 2000 ;
