4-甲氧基苯基氨基甲酸叔丁酯合成路线 （共 34 条）
反应条件
Yield given. Multistep reaction;
参考文献
Cho; Gong; Muchowski
Journal of Organic Chemistry, 1991 , vol. 56, # 26 p. 7288 - 7291
反应条件
1: 86 percent / NaH / tetrahydrofuran 2: 1.) n-BuLi, (-)-sparteine / 1.) toluene, -78 deg C, 4 h, 2.) toluene, -78 deg C -> room temperature 3: ammonium cerium(IV) nitrate / acetonitrile; H2O / 0.5 h / 0 °C 4: NaIO4, RuCl3*H2O / CCl4; acetonitrile; H2O / 48 h / Ambient temperature 5: 1.) thionyl chloride, 2.) di-tert-butyl dicarbonate / 1.) 2 h, 2.) CH2Cl2 View Scheme
参考文献
Kim, Bong Jin; Park, Yong Sun; Beak, Peter
Journal of Organic Chemistry, 1999 , vol. 64, # 5 p. 1705 - 1708
反应条件
1: With tert.-butyl lithium in diethyl ether 2: With 1,2-di-iodoethane in diethyl ether T=-78 - 20°C; Further stages.;
参考文献
Edwankar, Chitra R.; Edwankar, Rahul V.; Namjoshi, Ojas A.; Liao, Xuebin; Cook, James M.
Journal of Organic Chemistry, 2013 , vol. 78, # 13 p. 6471 - 6487
反应条件
1: 1.) t-BuLi, 2.) I2 / 1.) Et2O, pentane, -20 deg C, 3 h, 2.) Et2O, pentane, -100 deg C -> rt, overnight 2: 93 percent / CuI, Pd(PPh3)2Cl2 / triethylamine / 24 h / Ambient temperature 3: 67 percent / t-BuOK / 2-methyl-propan-2-ol / 17 h / Heating View Scheme
参考文献
Kondo, Yoshinori; Kojima, Satoshi; Sakamoto, Takao
Journal of Organic Chemistry, 1997 , vol. 62, # 19 p. 6507 - 6511
反应条件
1: 86 percent / NaH / tetrahydrofuran 2: 1.) n-BuLi, (-)-sparteine / 1.) toluene, -78 deg C, 4 h, 2.) toluene, -78 deg C -> room temperature 3: ammonium cerium(IV) nitrate / acetonitrile; H2O / 0.5 h / 0 °C 4: NaIO4, RuCl3*H2O / CCl4; acetonitrile; H2O / 48 h / Ambient temperature View Scheme
参考文献
Kim, Bong Jin; Park, Yong Sun; Beak, Peter
Journal of Organic Chemistry, 1999 , vol. 64, # 5 p. 1705 - 1708
反应条件
1.1: t-BuLi / pentane; diethyl ether / 3 h / -20 °C 1.2: 86 percent / 1,2-diiodoethane / pentane; diethyl ether / 16 h / -78 - 20 °C 2.1: 89 percent / CF3COOH / CH2Cl2 / 2 h / 20 °C View Scheme
参考文献
Sharp, Phillip P.; Banwell, Martin G.; Renner, Jens; Lohmann, Klaas; Willis, Anthony C.
Organic Letters, 2013 , vol. 15, # 11 p. 2616 - 2619
反应条件
tert.-butyl lithium 1.) THF, 2.) THF, reflux; Yield given. Multistep reaction;
参考文献
Reed, J. Norman; Rotchford, Judy; Strickland, Dean
Tetrahedron Letters, 1988 , vol. 29, # 45 p. 5725 - 5728
反应条件
in water
T=150°C; Green chemistry;
参考文献
Medina-Ramos, Wilmarie; Mojica, Mike A.; Cope, Elizabeth D.; Hart, Ryan J.; Pollet, Pamela; Eckert, Charles A.; Liotta, Charles L.
Green Chemistry, 2014 , vol. 16, # 4 p. 2147 - 2155
反应条件
1: water / 0.67 h / 150 °C / |Green chemistry
2: water / 150 °C / |Green chemistry
View Scheme
参考文献
Medina-Ramos, Wilmarie; Mojica, Mike A.; Cope, Elizabeth D.; Hart, Ryan J.; Pollet, Pamela; Eckert, Charles A.; Liotta, Charles L.
Green Chemistry, 2014 , vol. 16, # 4 p. 2147 - 2155
反应条件
1: 1.) t-BuLi, 2.) Bu3SnCl, 3.) Pd(PPh3)2Cl2
2: 99 percent / KNH2 / liquid ammonia / 3 h / -33 °C
View Scheme
参考文献
Iwao, Masatomo; Takehara, Hirokazu; Furukawa, Sunao; Watanabe, Mitsuaki
Heterocycles, 1993 , vol. 36, # 7 p. 1483 - 1488
