1-环己烯基-1-甲酸甲酯合成路线 （共 62 条）
反应条件
T=120°C; anschl.Erhitzen mit Methanol;
参考文献
Helvetica Chimica Acta, , vol. 17, p. 1218,1219
反应条件
multistep reaction; cata. decarbonylation with chlorocarbonylbis(triphenylphosphan)rhodium; Product distribution;
参考文献
Liebigs Annalen der Chemie, , # 8 p. 1394 - 1406
反应条件
1: 99 percent / DIBAL / diethyl ether / 1.) -70 deg C, 1 h, 2.) -70 -> -30 deg C, 1 h 2: 1.) oxalyl chloride, DMSO, 2.) Et3N / 1.) CH2Cl2, -60 deg C, 1 h, 2.) CH2Cl2, -20 deg C, 2 h 3: 13.7 g / R-oxynitrilase (E.C. 4.1.2.10) / various solvent(s) / 20 h View Scheme
参考文献
Warmerdam; Van Den Nieuwendijk; Kruse; Brussee; Van Der Gen
Recueil des Travaux Chimiques des Pays-Bas-Journal of the Royal Netherlands, 1996 , vol. 115, # 1 p. 20 - 24
反应条件
N,N,N',N',N'',N''-hexamethylphosphoric triamide; samarium diiodide in tetrahydrofuran 0.5 h; Ambient temperature;
参考文献
Cabrera; Alper
Tetrahedron Letters, 1992 , vol. 33, # 35 p. 5007 - 5008
反应条件
1: DBU / methanol 2: H2 / PtO2 / ethanol View Scheme
参考文献
Johnson, Matthew R.; Gauuan, Jolicia F.; Guo, Cheng; Guzzo, Peter R.; Le, Van-Duc; Shenoy, Rajesh A.; Hamby, James; Roark, Howard; Stier, Michael; Mangette, John E.
Synthetic Communications, 2011 , vol. 41, # 18 p. 2769 - 2793
反应条件
1: 99 percent / DIBAL / diethyl ether / 1.) -70 deg C, 1 h, 2.) -70 -> -30 deg C, 1 h 2: 1.) oxalyl chloride, DMSO, 2.) Et3N / 1.) CH2Cl2, -60 deg C, 1 h, 2.) CH2Cl2, -20 deg C, 2 h View Scheme
参考文献
Warmerdam; Van Den Nieuwendijk; Kruse; Brussee; Van Der Gen
Recueil des Travaux Chimiques des Pays-Bas-Journal of the Royal Netherlands, 1996 , vol. 115, # 1 p. 20 - 24
反应条件
potassium hydroxide in methanol 2 h; Heating;
参考文献
Palaty; Abbott
Journal of Medicinal Chemistry, 1995 , vol. 38, # 17 p. 3398 - 3406
反应条件
1: 1.) LiAlH4, 2.) PBr3 2: 1.) n-butyllithium, tetramethylethylenediamine, 2.) CuI / 1.) THF-hexane, room temperature, 2 h; 2.) -78 -> -40 deg C, 90 min, 3.) room temperature, 16 h 3: 1.) n-butyllithium, tetramethylethylenediamine / 1.) hexane, room temperature, 3 h, 2.) -78 deg C -> room temperature (16 h) 4: 92 percent / 4N hydrochloric acid / propan-2-ol; diethyl ether / 16 h / Ambient temperature View Scheme
参考文献
Bradbury, Barton J.; Sindelar, Robert D.
Journal of Heterocyclic Chemistry, 1989 , vol. 26, p. 1827 - 1833
反应条件
1: 98 percent / LiAlH4, decahydrated sodium sulfate / diethyl ether / 2 h / 0 °C 2: 93 percent / triphenylphosphine, CCl4 / CH2Cl2 / Heating View Scheme
参考文献
Ardolino, Michael J.; Morken, James P.
Journal of the American Chemical Society, 2014 , vol. 136, # 19 p. 7092 - 7100
