(S)-2-((2-氟苯氧基)甲基)环氧乙烷合成路线 （共 3 条）
反应条件
di-isopropyl azodicarboxylate; triphenylphosphine in tetrahydrofuran T=0 - 20°C; 16 h;
参考文献
BRISTOL-MYERS SQUIBB PHARMA COMPANY
Patent: WO2008/83054 A2, 2008 ;
Location in patent: Page/Page column 39 ;
WO 2008/083054 A2
反应条件
1: With 2,2,2-trifluoro-1,1-bis(trifluoromethyl)ethanol; chiral polymer-supported Co(salen) complex T=4 - 25°C; 6 h; 2: With potassium hydroxide in diethyl ether T=25°C; 3 h; Further stages. Title compound not separated from byproducts.;
参考文献
Peukert, Stefan; Jacobsen, Eric N.
Organic Letters, 1999 , vol. 1, # 8 p. 1245 - 1248
反应条件
potassium carbonate T=50°C; Alkylation; 18 h;
参考文献
Van Niel, Monique B.; Beer, Margaret S.; Castro, Jose L.; Cheng, Susan K.F.; Evans, David C.; Heald, Anne; Hitzel, Laure; Hunt, Peter; Mortishire-Smith, Russell; O'Connor, Desmond; Watt, Alan P.; MacLeod, Angus M.
Bioorganic and Medicinal Chemistry Letters, 1999 , vol. 9, # 22 p. 3243 - 3248
