(3R,4R)-二氢-3,4-二羟基-3-甲基-2(3H)-呋喃酮合成路线 （共 13 条）
反应条件
trifluoroacetic acid in water
T=0 - 20°C;
参考文献
Koumbis, Alexandros E.; Kaitaidis, Apostolos D.; Kotoulas, Stefanos S.
Tetrahedron Letters, 2006 , vol. 47, # 48 p. 8479 - 8481
反应条件
hydrogen; palladium on activated charcoal in ethanol; acetic acid
8 h;
参考文献
Juji, Yoshimura; Kazutoshi, Hara; Masanori, Yamaura
Carbohydrate Research, 1982 , vol. 101, p. 343 - 347
反应条件
potassium carbonate in methanol
T=0 - 20°C;
参考文献
Gogoi, Sanjib; Argade, Narshinha P.
Tetrahedron Asymmetry, 2006 , vol. 17, # 6 p. 927 - 932
反应条件
1: With acetic acid in water
T=80°C; 1 h;
2: With water; CaO
T=20 - 70°C; 16 h;
3: With Amberlite IR-120 in water
T=20°C; Product distribution / selectivity;
参考文献
THE CHANCELLORS, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD; IDENIX PHARMACEUTICALS, INC.; NOVARTIS AG
Patent: WO2007/25304 A2, 2007 ;
Location in patent: Page/Page column 38-39; 4/6 ;
反应条件
1: 1.) sulfur trioxide-pyridine complex, Et3N, 2.) aq. NaClO2, 2-methyl-2-butene, NaH2PO4*2H2O / 1.) DMSO, RT, 1 h, 2.) t-BuOH, RT, 18 h
2: diethyl ether
3: H2 / Pd(OH)2 / ethanol / Ambient temperature
4: camphorsulphonic acid / benzene / 1 h / Heating
View Scheme
参考文献
Marco, J. Alberto; Carda, Miguel; Gonzalez, Florenci; Rodriguez, Santiago; Murga, Juan; Falomir, Eva
Anales de Quimica, 1995 , vol. 91, # 1-2 p. 103 - 112
反应条件
1: H2 / Pd(OH)2 / ethanol / Ambient temperature
2: camphorsulphonic acid / benzene / 1 h / Heating
View Scheme
参考文献
Marco, J. Alberto; Carda, Miguel; Gonzalez, Florenci; Rodriguez, Santiago; Murga, Juan; Falomir, Eva
Anales de Quimica, 1995 , vol. 91, # 1-2 p. 103 - 112
参考文献
Hotchkiss, David J.; Soengas, Raquel; Booth, Kathrine V.; Weymouth-Wilson, Alexander C.; Eastwick-Field, Vanessa; Fleet, George W.J.
Tetrahedron Letters, 2007 , vol. 48, # 4 p. 517 - 520
反应条件
hydrogen fluoride in acetonitrile
Ambient temperature;
参考文献
Kobayashi; Horibe; Saito
Tetrahedron, 1994 , vol. 50, # 32 p. 9629 - 9642
反应条件
1: 98 percent / imidazole / CH2Cl2 / 20 °C
2: 96 percent / LiAlH4 / tetrahydrofuran / 60 °C
3: 99 percent / TBAF; AcOH / tetrahydrofuran / 0 - 20 °C
4: 89 percent / CrO3; pyridine; Ac2O / CH2Cl2 / 20 °C
5: 95 percent / TFA / H2O / 0 - 20 °C
View Scheme
参考文献
Koumbis, Alexandros E.; Kaitaidis, Apostolos D.; Kotoulas, Stefanos S.
Tetrahedron Letters, 2006 , vol. 47, # 48 p. 8479 - 8481
反应条件
1: 99 percent / TBAF; AcOH / tetrahydrofuran / 0 - 20 °C
2: 89 percent / CrO3; pyridine; Ac2O / CH2Cl2 / 20 °C
3: 95 percent / TFA / H2O / 0 - 20 °C
View Scheme
参考文献
Koumbis, Alexandros E.; Kaitaidis, Apostolos D.; Kotoulas, Stefanos S.
Tetrahedron Letters, 2006 , vol. 47, # 48 p. 8479 - 8481
