N,N-二甲基-4-溴苯甲酰胺合成路线 （共 28 条）
反应条件
1: With triethylamine in tetrahydrofuran; dichloromethane T=20°C; 1 h; 2: With hydrogenchloride in tetrahydrofuran; dichloromethane; water T=20°C;
参考文献
ASTRAZENECA AB; ASTRAZENECA UK LIMITED
Patent: WO2006/64251 A1, 2006 ;
Location in patent: Page/Page column 60 ;
WO 2006/064251 A1
反应条件
1: 1-(4-bromophenyl)-carbamide With sodium hydride in N,N-dimethyl-formamide T=0 - 20°C; 1.01667 - 1.03333 h; 2: methyl iodide in N,N-dimethyl-formamide T=20°C; 16 h;
参考文献
CURIS, INC.
Patent: WO2008/57497 A2, 2008 ;
Location in patent: Page/Page column 233-234 ;
反应条件
tert.-butylhydroperoxide; tetra-(n-butyl)ammonium iodide in trichloroethane, 1,1,2-; water T=90°C; 12 h; Reagent/catalystSolventTemperature;
参考文献
Li, Huamin; Xie, Jin; Xue, Qicai; Cheng, Yixiang; Zhu, Chengjian
Tetrahedron Letters, 2012 , vol. 53, # 48 p. 6479 - 6482,4
反应条件
tert.-butylhydroperoxide; tetra-(n-butyl)ammonium iodide in trichloroethane, 1,1,2-; water T=90°C; 24 h;
参考文献
Liu, Zhaojun; Zhang, Jie; Chen, Shulin; Shi, Erbo; Xu, Yuan; Wan, Xiaobing
Angewandte Chemie - International Edition, 2012 , vol. 51, # 13 p. 3231 - 3235
反应条件
oxygen; sodium hydroxide in water T=25°C; 24 h;
参考文献
Wang, Wentao; Cong, Yu; Zhang, Leilei; Huang, Yanqiang; Wang, Xiaodong; Zhang, Tao
Tetrahedron Letters, 2014 , vol. 55, # 1 p. 124 - 127
反应条件
1: p-bromophenyl bromide With n-butyllithium in tetrahydrofuran; hexane T=-78°C; 0.5 h; 2: N,N-dimethyl-formamide in tetrahydrofuran; hexane T=-78 - 20°C; 2 h; 3: methanol Further stages;
参考文献
Tetrahedron, , vol. 68, # 24 p. 4701 - 4709
反应条件
trichlorophosphate; tris(dibenzylideneacetone)dipalladium (0) T=120°C; 36 h;
参考文献
Hosoi, Kazushi; Nozaki, Kyoko; Hiyama, Tamejiro
Organic Letters, 2002 , vol. 4, # 17 p. 2849 - 2851
反应条件
thionyl chloride T=150°C; 5 h; Inert atmosphere;
参考文献
Kumagai, Takashi; Anki, Tomohiro; Ebi, Takahiro; Konishi, Akihito; Matsumoto, Kouzou; Kurata, Hiroyuki; Kubo, Takashi; Katsumoto, Kenta; Kitamura, Chitoshi; Kawase, Takeshi
Tetrahedron, 2010 , vol. 66, # 46 p. 8968 - 8973
反应条件
palladium diacetate; triethylamine in tetrahydrofuran Heating;
参考文献
Sierra; Mancheno; Saez; Del Amo
Journal of the American Chemical Society, 1998 , vol. 120, # 27 p. 6812 - 6813
反应条件
copper(I) oxide; 1,10-phenanthroline; oxygen; toluene-4-sulfonic acid T=140°C; P=760.051 Torr; 24 h; Sealed tube;
参考文献
Hu, Chenxu; Yan, Xufei; Zhou, Xiangge; Li, Zhengkai
Organic and Biomolecular Chemistry, 2013 , vol. 11, # 47 p. 8179 - 8182
