1-苄基-2-乙基-5-羟基-1H-吲哚-3-羧酸甲酯合成路线 （共 5 条）
反应条件
in nitromethane 48 h; Ambient temperaturefurther solvents;
参考文献
Pawlak; Khau; Hutchison; Martinelli
Journal of Organic Chemistry, 1996 , vol. 61, # 25 p. 9055 - 9059
反应条件
1: 95.7 percent / p-toluenesulfonic acid monohydrate / toluene / 3 h / Heating 2: 1.68 g / nitromethane / 48 h / 20 °C View Scheme
参考文献
Pawlak; Khau; Hutchison; Martinelli
Journal of Organic Chemistry, 1996 , vol. 61, # 25 p. 9055 - 9059
反应条件
1: p-TsOH*H2O / toluene / 4 h / Heating 2: 69 percent / nitromethane / 48 h / Ambient temperature; further solvents View Scheme
参考文献
Maguire, Anita R.; Plunkett, Stephen J.; Papot, Sebastien; Clynes, Martin; O'Connor, Robert; Touhey, Samantha
Bioorganic and Medicinal Chemistry, 2001 , vol. 9, # 3 p. 745 - 762
反应条件
in nitromethane T=20°C; 48 h;
参考文献
Maguire, Anita R.; Plunkett, Stephen J.; Papot, Sebastien; Clynes, Martin; O'Connor, Robert; Touhey, Samantha
Bioorganic and Medicinal Chemistry, 2001 , vol. 9, # 3 p. 745 - 762
反应条件
1: 60.6 percent / tetrabutylammonium bromide; aq. NaOH / 0.5 h / Heating
2: 66.4 percent / LiAlH4 / tetrahydrofuran / 17 h / 20 °C
3: 71.3 percent / BF3*OEt2 / CH2Cl2 / 1 h / 0 °C
4: 66.2 percent / KOH / 2-methyl-propan-2-ol / 1 h / Heating
View Scheme
参考文献
Pawlak; Khau; Hutchison; Martinelli
Journal of Organic Chemistry, 1996 , vol. 61, # 25 p. 9055 - 9059
