n-butyllithium; triphenylemethane in tetrahydrofuran; hexane T=-78°C; 0.333333 h;

T=120°C; Acylation;

1: 100 percent / Amberlyst-15 / 1.17 h / Heating 2: 70 percent / LiAlH4 / tetrahydrofuran / 0.67 h / 20 °C 3: 90 percent / HCl; NaNO2; H2O / ethyl acetate / 0.08 h / 20 °C 4: 97 percent / 120 °C View Scheme

1: 73 percent / H2O; Adzuki bean D-hydantoinase / various solvent(s) / 48 h / 40 °C / pH 9.0 / Enzymatic reaction 2: 100 percent / Amberlyst-15 / 1.17 h / Heating 3: 70 percent / LiAlH4 / tetrahydrofuran / 0.67 h / 20 °C 4: 90 percent / HCl; NaNO2; H2O / ethyl acetate / 0.08 h / 20 °C 5: 97 percent / 120 °C View Scheme

1: 90 percent / HCl; NaNO2; H2O / ethyl acetate / 0.08 h / 20 °C 2: 97 percent / 120 °C View Scheme

1: 70 percent / LiAlH4 / tetrahydrofuran / 0.67 h / 20 °C 2: 90 percent / HCl; NaNO2; H2O / ethyl acetate / 0.08 h / 20 °C 3: 97 percent / 120 °C View Scheme

1: in N,N-dimethyl-formamide T=-30 - 0°C; 3.83333 h; 2: With water in N,N-dimethyl-formamide T=0°C;