4-{2-[5-(2-甲基-1,3-二氧戊环-2-基)-2-吡啶基]乙氧基}苯甲醛合成路线 （共 6 条）
反应条件
triphenylphosphine; diethylazodicarboxylate in tetrahydrofuran 18 h; Ambient temperature;
参考文献
Tanis, Steven P.; Parker, Timothy T.; Colca, Jerry R.; Fisher, Roberta M.; Kletzein, Rolf F.
Journal of Medicinal Chemistry, 1996 , vol. 39, # 26 p. 5053 - 5063
反应条件
1: 92 percent / pTsOH / toluene / 8 h / Heating 2: 24 percent / H2O / 5 h / 150 °C 3: 55 percent / diethyl azodicarboxylate, Ph3P / tetrahydrofuran / 18 h / Ambient temperature View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 39, # 26 p. 5053 - 5063
反应条件
1: NaH / dimethylformamide; toluene / 2.5 h / 80 °C 2: 10percent aq. H2SO4 / 2 h / Heating 3: 92 percent / pTsOH / toluene / 8 h / Heating 4: 24 percent / H2O / 5 h / 150 °C 5: 55 percent / diethyl azodicarboxylate, Ph3P / tetrahydrofuran / 18 h / Ambient temperature View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 39, # 26 p. 5053 - 5063
反应条件
1: 10percent aq. H2SO4 / 2 h / Heating 2: 92 percent / pTsOH / toluene / 8 h / Heating 3: 24 percent / H2O / 5 h / 150 °C 4: 55 percent / diethyl azodicarboxylate, Ph3P / tetrahydrofuran / 18 h / Ambient temperature View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 39, # 26 p. 5053 - 5063
反应条件
1: 24 percent / H2O / 5 h / 150 °C 2: 55 percent / diethyl azodicarboxylate, Ph3P / tetrahydrofuran / 18 h / Ambient temperature View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 39, # 26 p. 5053 - 5063
反应条件
1: 56 percent / piperidine / ethanol / 18 h / Heating 2: 96 percent / NaBH4, 1.0N aq. NaOH, CoCl2*6H2O, dimethylglyoxime / dimethylformamide; tetrahydrofuran / 18 h / Ambient temperature View Scheme
参考文献
Tanis, Steven P.; Parker, Timothy T.; Colca, Jerry R.; Fisher, Roberta M.; Kletzein, Rolf F.
Journal of Medicinal Chemistry, 1996 , vol. 39, # 26 p. 5053 - 5063
