2-氯-1-甲基-1H-苯并咪唑合成路线 （共 18 条）
反应条件
1: 2-Chloro-1H-1,3-benzimidazole With sodium hydride in N,N-dimethyl-formamide T=0°C; 0.25 h; 2: methyl iodide in N,N-dimethyl-formamide T=0°C; 0.25 h;
参考文献
Zornik, Denise; Meudtner, Robert M.; Ela Malah, Tamer; Thiele, Christina M.; Hecht, Stefan
Chemistry - A European Journal, 2011 , vol. 17, # 5 p. 1473 - 1484
反应条件
triethanolamine T=20°C; SonicationGreen chemistry;
参考文献
Babu, P. N. Kishore; Devi, B. Rama; Dubey, P. K.
Asian Journal of Chemistry, 2012 , vol. 24, # 12 p. 5756 - 5758,3
反应条件
trichlorophosphate T=95°C; 1.5 h;
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 24, # 4 p. 1071 - 1074
反应条件
NaH; methyl iodide in N,N-dimethyl-formamide; mineral oil
参考文献
American Home Products Corporation
Patent: US5149700 A1, 1992 ;
反应条件
1: in tetrahydrofuran; hexane T=-78°C; 1 h; 2: With tetrachloromethane in tetrahydrofuran; hexane T=-78°C; 1.5 h;
参考文献
Organic and Biomolecular Chemistry, , vol. 9, # 20 p. 7092 - 7096
反应条件
n-butyllithium; 2,2,2-trichloroacetyl chloride in tetrahydrofuran; hexane T=-70°C; Metallation; substitution; 0.5 h;
参考文献
Boga, Carla; Del Vecchio, Erminia; Forlani, Luciano; Milanesi, Lilia; Edgardo Todesco, Paolo
Journal of Organometallic Chemistry, 1999 , vol. 588, # 2 p. 155 - 159
反应条件
Cu2Cl2; hydrogenchloride; selenium(IV) oxide in water 1) 20 to 25 deg C 2) heating to boiling point;
参考文献
Sedov, Yu. A.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1983 , p. 217 - 220
Khimiya Geterotsiklicheskikh Soedinenii, 1983 , vol. 19, # 2 p. 265 - 267
反应条件
sodium hydride 1.) DMF, RT, 1 h, 2.) DMF, 1 h; Multistep reaction;
参考文献
Journal of Medicinal Chemistry, , vol. 40, # 4 p. 586 - 593
反应条件
1: tetrahydrofuran; dichloromethane / 6.5 h / 20 °C 2: trichlorophosphate / 1.5 h / 95 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 24, # 4 p. 1071 - 1074
反应条件
water; lithium 1) THF, room temperature, 2) THF, room temperature; reflux; Yield given. Multistep reaction;
参考文献
Aksenov; Aksenova; Borovlev; Smushkevich
Chemistry of Heterocyclic Compounds, 1997 , vol. 33, # 8 p. 954 - 958
