2-氯-1-甲基-1H-苯并咪唑合成路线 （共 18 条）
反应条件
hydrogenchloride; sulfuric acid; nitric acid; tin(ll) chloride 1.) 10 deg C, 1 h, 2.) 100 deg C, 4 h; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Galy, Jean-Pierre; Hanoun, Jean-Pierre; Pique, Valerie; Jagerovic, Nadine; Elguero, Jose
Journal of Heterocyclic Chemistry, 1997 , vol. 34, # 6 p. 1781 - 1787
反应条件
sulfuric acid; nitric acid T=10°C; 1 h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Galy, Jean-Pierre; Hanoun, Jean-Pierre; Pique, Valerie; Jagerovic, Nadine; Elguero, Jose
Journal of Heterocyclic Chemistry, 1997 , vol. 34, # 6 p. 1781 - 1787
反应条件
1: hydrazine hydrate / 160 °C 2: hydrogenchloride; sodium nitrite / ethanol; water / 0 °C View Scheme
参考文献
Zornik, Denise; Meudtner, Robert M.; Ela Malah, Tamer; Thiele, Christina M.; Hecht, Stefan
Chemistry - A European Journal, 2011 , vol. 17, # 5 p. 1473 - 1484
反应条件
hydrazine hydrate
T=160°C;
参考文献
Zornik, Denise; Meudtner, Robert M.; Ela Malah, Tamer; Thiele, Christina M.; Hecht, Stefan
Chemistry - A European Journal, 2011 , vol. 17, # 5 p. 1473 - 1484
反应条件
in water
T=160°C; 15 h; Yield given;
参考文献
Benassi, Rois; Grandi, Romano; Pagnoni, Ugo M.; Taddei, Ferdinando; Bocelli, Gabriele; Sgarabotto, Paolo
Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1985 , p. 1513 - 1522
反应条件
in N,N-dimethyl-formamide
T=100°C; 2 h;
参考文献
Luo, Yu; Xiao, Feng; Qian, Shijing; Lu, Wei; Yang, Bo
European Journal of Medicinal Chemistry, 2011 , vol. 46, # 1 p. 417 - 422
反应条件
1: neat (no solvent) / 1 h / 125 °C
2: hydrogen bromide / water / 24 h / 70 °C
3: triethylamine / dichloromethane / 0 - 20 °C
View Scheme
参考文献
Hofer, Sandra; Kratschmar, Denise V.; Schernthanner, Brigitte; Vuorinen, Anna; Schuster, Daniela; Odermatt, Alex; Easmon, Johnny
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 19 p. 5397 - 5400
反应条件
1: neat (no solvent) / 1 h / 125 °C
2: hydrogen bromide / water / 24 h / 70 °C
3: triethylamine / dichloromethane / 0 - 20 °C
View Scheme
参考文献
Hofer, Sandra; Kratschmar, Denise V.; Schernthanner, Brigitte; Vuorinen, Anna; Schuster, Daniela; Odermatt, Alex; Easmon, Johnny
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 19 p. 5397 - 5400
